1. The neutrophil‐to‐lymphocyte ratio represents a systemic inflammation marker and reflects the relationship with 90‐day mortality in non‐cirrhotic chronic severe hepatitis
- Author
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Fu Chen Dong, Wen Ting Tan, Xian Bo Wang, Xin Zheng, Yan Huang, Bei Ling Li, Zhong Ji Meng, Yan Hang Gao, Zhi Ping Qian, Feng Liu, Xiao Bo Lu, Jia Shang, Yu Shi, Yu Bao Zheng, Hua Dong Yan, Yan Zhang, Bao Yan Xu, Yi Xin Hou, Qun Zhang, Yan Xiong, Cong Cong Zou, Jun Chen, Ze Bing Huang, Xiu Hua Jiang, Sen Luo, Yuan Yuan Chen, Na Gao, Chun Yan Liu, Wei Yuan, Xue Mei, Jing Li, Tao Li, Rong Jiong Zheng, Xin Yi Zhou, Jin Jun Chen, Guo Hong Deng, Xiang Xiao Mei, Wei Tuo Zhang, and Hai Li
- Subjects
Inflammation ,Neutrophils ,Gastroenterology ,Humans ,Lymphocytes ,Prognosis ,Retrospective Studies ,Hepatitis - Abstract
To investigate the relationship between systemic inflammatory response and short-term mortality in patients with non-cirrhotic chronic severe hepatitis (CSH) by using several indicators of inflammation including neutrophil-to-lymphocyte ratio (NLR), neutrophil (NEU), white blood cell (WBC), platelet-to lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR).Data were collected from two prospectively enrolled CATCH-LIFE noncirrhotic cohorts. Cox regression analysis was used to investigate the association between systemic inflammatory biomarkers and 90-day liver transplant (LT)-free mortality. A generalized additive model (GAM) was used to illustrate the quantitative curve relationship between NLR and 90-day LT-free mortality. Kaplan-Meier method was used to estimate the 90-year LT-free survival.The prevalence of CSH was 20.5% (226/1103). The 28-day and 90-day LT-free mortality rates were 17.7% and 26.1%, respectively, for patients with non-cirrhotic CSH. Patients with no infection accounted for 75.0% of all CSH patients, and NLR was independently associated with 90-day LT-free mortality. NLR of 2.9 might be related to disease deterioration in CSH patients without infection.NLR may be an independent risk factor for 90-day LT-free mortality in patients with non-cirrhotic chronic liver disease. A NLR of 2.9 as the cut-off value can be used to predict disease aggravation in CSH patients without infection.
- Published
- 2022