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Abstract: In this paper, we study the dynamics of predator–prey interaction systems between two species with ratio-dependent functional responses. First we provide sufficient and necessary conditions for positive steady-state solutions, and then we investigate the relationships between positive equilibria and positive solutions of the system over a large domain. Furthermore, we deal with the uniqueness and the stability of positive steady-states solutions with some assumptions. In addition, we discuss the extinction and the persistence results of time-dependent positive solutions to the system. [Copyright &y& Elsevier]