1. Serum pigment epithelium-derived factor: Relationships with cardiovascular events, renal dysfunction, and mortality in the Veterans Affairs Diabetes Trial (VADT) cohort
- Author
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Danielle R. Stevens, Dongxu Fu, Vadt Investigators, Timothy J. Lyons, Maria F. Lopes-Virella, Kelly J. Hunt, Madona Azar, Richard L. Klein, Jian Xing Ma, Sarah X. Zhang, and Alicia J. Jenkins
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Gastroenterology ,Article ,Nephropathy ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,PEDF ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,Medicine ,Albuminuria ,Humans ,Diabetic Nephropathies ,Nerve Growth Factors ,Risk factor ,Renal Insufficiency, Chronic ,Eye Proteins ,Veterans Affairs ,Serpins ,Veterans ,Creatinine ,business.industry ,Middle Aged ,medicine.disease ,chemistry ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Female ,business ,Biomarkers ,Diabetic Angiopathies ,Kidney disease ,Glomerular Filtration Rate - Abstract
BACKGROUND: To determine if serum pigment epithelium-derived factor (PEDF) levels predict cardiovascular events, renal dysfunction and mortality in the Veterans Affairs Diabetes Study (VADT). METHODS: PEDF was evaluated in relation to subsequent cardiovascular outcomes, mortality, and renal dysfunction (defined as urinary albumin creatinine ratio (ACR) ≥300 mg/g), or chronic kidney disease (CKD) stages 3 (eGFR
- Published
- 2019