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Your search keyword '"Tang, Wern Ee"' showing total 11 results
Start Over Author "Tang, Wern Ee" Journal journal of diabetes and its complications
11 results on '"Tang, Wern Ee"'

11. Leucine-rich α-2-glycoprotein predicts proliferative diabetic retinopathy in type 2 diabetes

Author

Su Chi Lim, Tang Wern Ee, Chee Chew Yip, Darren Yeo, Neelam Kumari, Sharon Li Ting Pek, Subramaniam Tavintharan, Chee Fang Sum, Keven Ang, and Xiao Zhang

Subjects
Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Fundus (eye), Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Vascular Stiffness, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Ethnicity, Humans, Pulse wave velocity, Aged, Glycoproteins, Singapore, Diabetic Retinopathy, business.industry, Diabetic retinopathy, Middle Aged, medicine.disease, eye diseases, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Relative risk, Carotid-Femoral Pulse Wave Velocity, Arterial stiffness, Disease Progression, Biomarker (medicine), Female, business, Biomarkers
Abstract

Aim We aim to examine the association of plasma leucine-rich-α-2-glycoprotein 1 (LRG1) with diabetic retinopathy (DR) in type 2 diabetes. Methods At baseline visit, plasma LRG1 levels were assessed using ELISA. Central arterial stiffness was estimated by carotid-femoral pulse wave velocity (PWV). At follow-up visit (median = 3.2 years), digital color fundus photographs were assessed for DR. DR severity was categorized into non-proliferative DR (NPDR) and proliferative DR (PDR). Results DR was diagnosed in 396 (32.8%) of 1206 patients. DR has higher LRG1 than non-DR (19.5 ± 11.3vs.16.9 ± 8.9 μg/ml, p ≪ 0.001). After adjustment, LRG1 was not associated with DR (OR = 1.2, [95% CI, 0.96–1.30], p = 0.16). LRG1 was higher in PDR (n = 107) than NPDR (n = 270) (23.2 ± 15.4vs.18.1 ± 8.9 μg/ml, n = 270, p ≪ 0.001). After adjustment, with 1-SD increase in LRG1, the relative risk of NPDR and PDR was 0.99 ([0.83–1.18], p = 0.91) and 1.42 ([95% CI, 1.14–1.76], p = 0.002) (p-trend = 0.01), respectively. We didn't observe significant improvement in AUC after adding LRG1 into the model. Baseline PWV mediated 12.0% of the association between LRG1 and PDR (p = 0.03). Conclusion Baseline plasma LRG1 is associated with PDR, suggesting it maybe a promising biomarker for prediction for advanced proliferative stages of DR. The mediation result indicates the potential benefit of ameliorating central arterial stiffness to prevent PDR.

Published
2018

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