1. T2D SNPs among Yup'ik people
- Author
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Klimentidis, Yann C, Lemas, Dominick J, Wiener, Howard H, O'Brien, Diane M, Havel, Peter J, Stanhope, Kimber L, Hopkins, Scarlett E, Tiwari, Hemant K, and Boyer, Bert B
- Subjects
Epidemiology ,Biomedical and Clinical Sciences ,Health Sciences ,Obesity ,Genetics ,Diabetes ,Nutrition ,Human Genome ,Prevention ,American Indian or Alaska Native ,2.1 Biological and endogenous factors ,Aetiology ,Metabolic and endocrine ,Adult ,Alaska ,Blood Glucose ,Body Mass Index ,Cyclin-Dependent Kinase 5 ,Diabetes Mellitus ,Type 2 ,Diet ,Fasting ,Fatty Acids ,Omega-3 ,Female ,Gene Frequency ,Genetic Predisposition to Disease ,Genotype ,Glycated Hemoglobin ,Homeodomain Proteins ,Humans ,Insulin ,Inuit ,Linear Models ,Male ,Middle Aged ,Polymorphism ,Single Nucleotide ,Prevalence ,Risk Factors ,Transcription Factors ,Young Adult ,tRNA Methyltransferases ,Alaska Native ,glycemic traits ,n-3 polyunsaturated fatty acids ,type 2 diabetes single nucleotide polymorphisms ,n-3 ,2 ,阿拉斯加原住民，血糖特征，n-3多不饱和脂肪酸，2型糖尿病单核苷酸多态性 ,Clinical Sciences ,Public Health and Health Services ,Clinical sciences - Abstract
BackgroundGenome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with type 2 diabetes (T2D), mainly among individuals of European ancestry. In the present study, we examined the frequency of these SNPs and their association with T2D-related traits in an Alaska Native study population with a historically low prevalence of T2D. We also investigated whether dietary characteristics that may protect against T2D, such as n-3 polyunsaturated fatty acid (PUFA) intake, modify these associations.MethodsIn 1144 Yup'ik people, we examined 17 SNPs repeatedly identified in GWAS for individual and cumulative associations with T2D-related traits. Cumulative associations were evaluated using a genetic risk score (GRS) calculated by summing risk alleles. Associations were tested for interactions with sex, body mass index (BMI), and n-3 PUFA intake.ResultsThe rs7754840 SNP in CDKAL1 is significantly associated with HbA1c (P = 0.00091). The rs5015480 SNP near HHEX is significantly associated (in opposite direction to that in Europeans) with a combined fasting glucose (FG) and HbA1c measure (P = 0.00046) and with homeostatic model assessment of β-cell function (HOMA-B; P = 0.0014). The GRS is significantly associated with FG and combined FG and HbA1c only when the HHEX SNP is dropped from the GRS. Associations are not modified by BMI or n-3 PUFA intake.ConclusionOur results highlight the potential importance of CDKAL1 and HHEX in glucose homeostasis in this Alaska Native population with a low prevalence of T2D, and suggest that these loci should be examined in greater detail in this population.
- Published
- 2014