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Abstract: Background: It is well known physical activity (PA) plays a role in the prevention of type 2 diabetes (T2D). However, the extent to which PA may affect T2D risk among different race–ethnic groups is unknown. Therefore, the aim of the present study was to systematically examine the effect modification of race–ethnicity on PA and T2D. Methods: The PubMed and Embase databases were systematically searched through June 2016. Study assessment for inclusion was conducted in three phases: title review (n = 13 022), abstract review (n = 2200), and full text review (n = 265). In all, 27 studies met the inclusion criteria and were used in the analysis. Relative risks (RRs) and 95% confidence intervals (CIs) were extracted and analyzed using Comprehensive Meta‐Analysis software. All analyses used a random‐effects model. Results: A significant protective summary RR, comparing the most active group with the least active PA group, was found for non‐Hispanic White (RR 0.71, 95% CI 0.60–0.85), Asians (RR 0.76, 95% CI 0.67–0.85), Hispanics (RR 0.75, 95% CI 0.64–0.89), and American Indians (RR 0.73, 95% CI 0.60–0.88). The summary effect for non‐Hispanic Blacks (RR 0.91, 95% CI 0.76–1.08) was not significant. Conclusions: The results of the present study indicate that PA (comparing most to least active groups) provides significant protection from T2D, with the exception of non‐Hispanic Blacks. The results also indicate a need for race–ethnicity‐specific reporting of RRs in prospective cohort studies that incorporate multiethnic samples. [ABSTRACT FROM AUTHOR]