1. Unique Tailoring of Th17 at the Gingival Oral Mucosal Barrier.
- Author
-
Konkel, J. E. and Moutsopoulos, N. M.
- Subjects
IMMUNOGENETICS ,ORAL hygiene ,ORAL mucosa ,CYTOKINES ,INTERLEUKIN-17 ,PHYSIOLOGY ,CELLULAR immunity ,IMMUNITY ,LYMPHOCYTES ,MASTICATION ,RESEARCH funding - Abstract
Our recent work highlights unique requirements for the induction of Th17 cells at the oral/gingival mucosal barrier. Unlike other barrier sites, such as the skin and gastrointestinal tract, we found that Th17 cells can develop at the gingiva independently of commensal microbiota colonization. Instead, we identified that damage, which occurs physiologically due to mastication, promotes induction of Th17 cells and tones homeostatic immunity at the gingiva. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF