1. Oral lupus erythematosus: markers of immunologic injury.
- Author
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Van Joost, Th., Stolz, E., van der Sluis, J. J., Vuzevski, V. D., and van der Kwast, Th. H.
- Subjects
ORAL mucosa diseases ,LUPUS erythematosus ,TONGUE ,SKIN diseases ,IMMUNOCYTOCHEMISTRY ,HLA histocompatibility antigens - Abstract
Tissue specimens were taken from three regions in a patient with oral progressive lupus erythematosus (LE): the tongue, the buccal mucosa and clinically uninvolved cutaneous tissue. They were subjected to immunocytochemical studies by use of markers. HLA-DR antigen expression on mucosal epithelial cells was found in association with a predominance of activated helper T-Cells in the lesional tissue. Langerhans cells (OKT-6) and B-cells (Leu-IO, B1 and B2) were nearly absent in the mucosal lesions. The presence of populations of macrophages (MY-4) in the lesional epithelium might suggest an important role for these cells, rather than for Langerhans cells, in the afferent limb of cellular immunity in this case of LE. [ABSTRACT FROM AUTHOR]
- Published
- 1985
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