1. Incidence and initial disease course of inflammatory bowel diseases in 2011 in Europe and Australia: Results of the 2011 ECCO-EpiCom inception cohort
- Author
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I. Kaimakliotis, Ebbe Langholz, A. De Padova, Sally Bell, Alberto Fernandez, I Mihu, Søren Avnstrøm, Adrian Goldis, Limas Kupčinskas, Daniela Lazăr, L. Barros, Svetlana Turcan, O Niewiadomski, EpiCom-group, Z. Vegh, K.H. Katsanos, J. Olsen, K R Nielsen, Shmuel Odes, Martin Bortlik, Laimas Virginijus Jonaitis, E.V. Tsianos, Peter L. Lakatos, Pia Munkholm, O Tighineanu, K. Kofod Vinding, Dana Duricova, Guido Lupinacci, Laszlo Lakatos, Vicent Hernandez, Fernando Magro, Johan Burisch, Niels C Pedersen, and Doron Schwartz
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Constriction, Pathologic ,Rate ratio ,Severity of Illness Index ,Inflammatory bowel diseases ,Epidemiology ,Europe ,Australia ,Inflammatory bowel disease ,Gastroenterology ,Cohort Studies ,Young Adult ,Crohn Disease ,Internal medicine ,Humans ,Medicine ,Mesalamine ,Aged ,Aged, 80 and over ,Crohn's disease ,business.industry ,Incidence ,Incidence (epidemiology) ,Anti-Inflammatory Agents, Non-Steroidal ,Smoking ,Colonoscopy ,General Medicine ,Middle Aged ,medicine.disease ,Ulcerative colitis ,616.34-002 [udc] ,digestive system diseases ,Cohort ,Colitis, Ulcerative ,Female ,Steroids ,business ,Immunosuppressive Agents ,Cohort study - Abstract
Background and aims: The aim of the present study was to validate the IBD (inflammatory bowel diseases) incidence reported in the 2010 ECCO-EpiCom (European Crohn's and Colitis Organization–Epidemiological Committee) inception cohort by including a second independent inception cohort from participating centers in 2011 and an Australian center to investigate whether there is a difference in the incidence of IBD between Eastern and Western European countries and Australia. Methods: Fourteen centers from 5 Eastern and 9 Western European countries and one center from Australia participated in the ECCO-EpiCom 2011 inception cohort. Patients' data regarding disease type, socio-demographic factors, extraintestinal manifestations and therapy were entered into the Web-based EpiCom database, www.ecco-epicom.eu. Results: A total of 711 adult patients were diagnosed during the inclusion year 2011, 178 (25%) from Eastern, 461 (65%) from Western Europe and 72 (10%) from Australia; 259 (37%) patients were diagnosed with Crohn's disease, 380 (53%) with ulcerative colitis and 72 (10%) with IBD unclassified. The mean annual incidence rate for IBD was 11.3/100,000 in Eastern Europe, 14.0/100,000 in Western Europe and 30.3/100,000 in Australia. Significantly more patients were diagnosed with complicated disease at diagnosis in Eastern Europe compared to Western Europe (43% vs. 27%, p = 0.02). Conclusion: Incidence rates, disease phenotype and initial treatment characteristics in the 2011 ECCO-EpiCom cohort were not significantly different from that reported in the 2010 cohort. * Abbreviations: : IBD : inflammatory bowel diseases CD : Crohn's disease UC : ulcerative colitis IBDU : inflammatory bowel disease unclassified ECCO : European Crohn's and Colitis Organization EpiCom : Epidemiological Committee IRR : incidence rate ratio CI : confidence interval EC-IBD : European Collaborative Study on Inflammatory Bowel Disease ACCESS : Asia-Pacific Crohn's and Colitis Epidemiology Study SE : standard error
- Published
- 2014