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Background: Chronic and recurrent dermatophytosis is adversely effecting the psychosocial well‐being of patients. Aims: To assess the impact of chronic and recurrent dermatophytosis on quality of life and psychological well‐being of patients. Methods: We performed a cross‐sectional study on patients of chronic and recurrent dermatophytosis aged >12 years. Clinical diagnosis was done, followed by appropriate investigations when required. The patients were made to fill up the questionnaires on Dermatology Life Quality Index, Hospital Anxiety and Depression Scale, and Perceived Stress Scale in English and local languages. The responses were coded with 4‐point Likert scale. Statistical analysis was done using MedCal®V.125.0. Results: Data of 123 patients were analyzed. Mean DLQI score was 21.4 ± 5.6 and main domain affected was "symptoms and feelings." CRD had an "extremely large effect" on QoL (DLQI score 21–30) in 55.3% patients. Mean HADS‐A(anxiety) score was 10.1 ± 3.6, and mean HADS‐D(depression) score of participants was 7.8 ± 3.2. Mean perceived stress scale (PSS) score was 18.8 ± 4.3. Involvement of >1 site was a risk factor for higher DLQI score suggestive of "extremely large impact" on QoL (OR 34.02,95% CI 5.7–203.2,p = 0.0001), higher/worsened HADS‐A score (OR 5.4, 95% CI 1.2–22.9, p = 0.02), and higher/worsened PSS score (OR 6.1, 95% CI 1.1–34.1, p = 0.04). Persistent disease >1 year (OR 11.5, 95% CI 1.9–67.8, p = 0.007) and male gender (OR 0.3, 95% CI 0.1–0.8, p = 0.01) were significant risk factors for anxiety while BSA involvement >10% was a significant risk factor for moderate to severe perceived stress(OR 13.9, 95% CI 1.5–130.7, p = 0.02). Conclusion: Chronic and recurrent dermatophytosis requires a multidisciplinary approach involving psychiatrists, to reduce the psychological burden. [ABSTRACT FROM AUTHOR]

Background: Acanthosis nigricans (AN) is a cutaneous disorder characterized by symmetric velvety hyperpigmented plaques on intertriginous areas like axilla, neck, inframammary, and groin. Aims: To summarize the pathophysiology and classification of AN, provide an update of diagnostic testing strategies, and describe the current therapeutic options described so far in the literature for this disease. Methods: A comprehensive english language literature search across multiple databases (PubMed, EMBASE, MEDLINE, and Cochrane) for keywords (alone and in combination) was performed. MeSH as well as non‐MeSH terms such as "acanthosis nigricans," "classification," "pathophysiology," "diagnosis," "treatment," "topical drugs," "systemic drugs," "chemical peeling," and "lasers" were taken into consideration. Results: The pathophysiology of AN revolves around a multifactorial stimulation of proliferation of epidermal keratinocytes and dermal fibroblasts. Various types of AN include benign, obesity‐associated, syndromic, malignant, acral, unilateral, medication‐induced, and mixed‐type. Homeostasis model assessment‐insulin resistance (HOMA‐IR) is a good tool for assessment of insulin resistance. Management involves general measures (weight reduction and addressing the underlying cause, if any), topical drugs (retinoids, vitamin D analogs, and keratolytics), oral drugs (retinoids and insulin sensitizers), chemical peels (trichloroacetic acid), and lasers (Long pulsed alexandrite, fractional 1550‐nm erbium fiber, and CO2). Conclusion: Acanthosis nigricans is a treatable condition; however, complete cure and disappearance of lesions are difficult to achieve. Weight reduction is the most scientific and practical management strategy. Long‐term studies and further research is warranted in the pathophysiology and treatment of this common condition. [ABSTRACT FROM AUTHOR]

Vasculitic lesions have been reported to develop in patients with COVID-19 infection. 2 Negrini S, Guadagno A, Greco M, Parodi A, Burlando M. An unusual case of bullous haemorrhagic vasculitis in a COVID-19 patient. Keywords: Koebnerization; post-Covid; vasculitis EN Koebnerization post-Covid vasculitis 2307 2308 2 06/23/22 20220601 NES 220601 CONFLICT OF INTEREST None. [Extracted from the article]