9 results on '"Pei Wang"'
Search Results
2. Deep learning applications in automatic segmentation and reconstruction in CT-based cervix brachytherapy
- Author
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Hai Hu, Qiang Yang, Jie Li, Pei Wang, Bin Tang, Xianliang Wang, and Jinyi Lang
- Subjects
deep learning ,applicator segmentation ,brachytherapy ,cervical cancer ,dosimetric comparison. ,Medicine - Published
- 2021
- Full Text
- View/download PDF
3. Dosimetric comparison of graphical optimization and inverse planning simulated annealing for brachytherapy of cervical cancer
- Author
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Bin Tang, Xiangyu Liu, Xianliang Wang, Shengwei Kang, Pei Wang, Jie Li, and Lucia Orlandini
- Subjects
cervical cancer ,3d brachytherapy ,optimization methods ,Medicine - Published
- 2019
- Full Text
- View/download PDF
4. An automated dose verification software for brachytherapy
- Author
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Xianliang Wang, Pei Wang, Churong Li, Wu Zhangwen, Gou Chengjun, Jie Li, Shengwei Kang, and Qing Hou
- Subjects
brachytherapy ,dose verification ,quality assurance ,treatment planning system ,Medicine - Published
- 2018
- Full Text
- View/download PDF
5. Image guided radiation therapy boost in combination with high-dose-rate intracavitary brachytherapy for the treatment of cervical cancer
- Author
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Xianliang Wang, Jie Li, Pei Wang, Ke Yuan, Gang Yin, and Bin Wan
- Subjects
cervical cancer ,HDR brachytherapy ,IGRT ,Medicine - Abstract
Purpose : The purpose of this study was to demonstrate the dosimetric and clinical feasibility of image guided radiation therapy (IGRT) combined with high-dose-rate (HDR) intracavitary brachytherapy (ICBT) to improve dose distribution in cervical cancer treatment. Material and methods: For 42 cervical cancer patients, magnetic resonance imaging (MRI) scans were acquired after completion of whole pelvic irradiation 45-46 Gy and 5 fractions of B + I (ICBT + IGRT) treatment were subsequently received. The high risk clinical target volume (HRCTV), intermediate risk clinical target volume (IRCTV), bladder, rectum, and sigmoid were contoured on the computed tomography (CT) scans. The total planning aim doses for HRCTV was D 90% > 85 Gy, whilst constraints for rectum and sigmoid were D 2cc < 75 Gy and D 2cc < 90 Gy for bladder in terms of an equivalent dose in 2 Gy (EQD2) for external beam radiotherapy (EBRT) and brachytherapy boost. The IGRT plan was optimized on top of the ICBT dose distribution. A dosimetric comparison was made between B + I and optimized ICBT (O-ICBT) only. Results: The mean D 90% of HRCTV was comparable for B + I and O-ICBT (p = 0.82). For B + I plan, HRCTV D100%, IRCTV D 100% , and IRCTV D 90% were significantly increased by a mean of 10.52 Gy, 5.61 Gy, and 2.70 Gy, respectively (p < 0.01). The D 2cc for bladder, rectum, and sigmoid were lower by a mean of 21.36, 6.78, and 10.65 Gy, respectively (p < 0.01). The mean rectum V60 Gy value over 42 patients was almost the same for both techniques but for bladder and sigmoid B + I had higher V60 Gy mean values as compared with the O-ICBT. Conclusions : B + I can improve dose distribution in cervical cancer treatment; it could be useful for tumors extended beyond the reach of intracavitary/interstitial brachytherapy (IC/ISBT) or for centers that are inexperienced or ill-equipped with IC/ISBT techniques. Additional confirmatory prospective studies with larger numbers of patients and longer follow-up are required to validate the durability.
- Published
- 2016
- Full Text
- View/download PDF
6. Dosimetric study for cervix carcinoma treatment using intensity modulated radiation therapy (IMRT) compensation based on 3D intracavitary brachytherapy technique
- Author
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Jinyi Lang, Yin Tian, Kin Yip Tam, Gang Yin, Zixuan Fan, Yangkun Luo, and Pei Wang
- Subjects
medicine.medical_specialty ,cervical cancer ,medicine.medical_treatment ,Brachytherapy ,brachytherapy ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Dosimetry ,Radiology, Nuclear Medicine and imaging ,Medical physics ,CERVIX CARCINOMA ,IMRT ,Cervical cancer ,Original Paper ,dosimetry ,business.industry ,Intracavitary brachytherapy ,Intensity-modulated radiation therapy ,medicine.disease ,Oncology ,030220 oncology & carcinogenesis ,business ,Nuclear medicine ,cervix carcinoma - Abstract
Purpose Intensity modulated radiation therapy (IMRT) compensation based on 3D high-dose-rate (HDR) intracavitary brachytherapy (ICBT) boost technique (ICBT + IMRT) has been used in our hospital for advanced cervix carcinoma patients. The purpose of this study was to compare the dosimetric results of the four different boost techniques (the conventional 2D HDR intracavitary brachytherapy [CICBT], 3D optimized HDR intracavitary brachytherapy [OICBT], and IMRT-alone with the applicator in situ). Material and methods For 30 patients with locally advanced cervical carcinoma, after the completion of external beam radiotherapy (EBRT) for whole pelvic irradiation 45 Gy/25 fractions, five fractions of ICBT + IMRT boost with 6 Gy/fractions for high risk clinical target volume (HRCTV), and 5 Gy/fractions for intermediate risk clinical target volume (IRCTV) were applied. Computed tomography (CT) and magnetic resonance imaging (MRI) scans were acquired using an in situ CT/MRI-compatible applicator. The gross tumor volume (GTV), the high/intermediate-risk clinical target volume (HRCTV/IRCTV), bladder, rectum, and sigmoid were contoured by CT scans. Results For ICBT + IMRT plan, values of D90, D100 of HRCTV, D90, D100, and V100 of IRCTV significantly increased (p < 0.05) in comparison to OICBT and CICBT. The D2cc values for bladder, rectum, and sigmoid were significantly lower than that of CICBT and IMRT alone. In all patients, the mean rectum V60 Gy values generated from ICBT + IMRT and OICBT techniques were very similar but for bladder and sigmoid, the V60 Gy values generated from ICBT + IMRT were higher than that of OICBT. For the ICBT + IMRT plan, the standard deviations (SD) of D90 and D2cc were found to be lower than other three treatment plans. Conclusions The ICBT + IMRT technique not only provides good target coverage but also maintains low doses (D2cc) to the OAR. ICBT + IMRT is an optional technique to boost parametrial region or tumor of large size and irregular shape when intracavitary/interstitial brachytherapy cannot be used.
- Published
- 2016
7. An automated dose verification software for brachytherapy
- Author
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Jie Li, Churong Li, Shengwei Kang, Xianliang Wang, Chengjun Gou, Qing Hou, Zhangwen Wu, and Pei Wang
- Subjects
medicine.medical_treatment ,Brachytherapy ,brachytherapy ,Planning target volume ,lcsh:Medicine ,quality assurance ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,DICOM ,0302 clinical medicine ,Software ,dose verification ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radiation treatment planning ,Original Paper ,Modular structure ,business.industry ,lcsh:R ,Oncology ,030220 oncology & carcinogenesis ,Dose verification ,treatment planning system ,business ,Nuclear medicine ,Quality assurance - Abstract
Purpose To report an implementation method and the results of independent brachytherapy dose verification software (DVS). Material and methods The DVS was developed based on Visual C++ and adopted a modular structure design. The DICOM RT files exported from a treatment planning system (TPS) were automatically loaded into the DVS. The DVS used the TG-43 formalism for dose calculation. A total of 15 cervical cancer patients who underwent brachytherapy were retrospectively selected to test the DVS. Dosimetric parameters and γ analysis (0.1 cm, 5%) were used to evaluate the dose differences between the DVS and the TPS. Results Compared with the TPS dose, the γ pass rates of the dose calculated by the DVS were higher than 98%. For the clinical target volume (CTV), the dosimetric differences were less than 0.63% for D90% and D100%. For the bladder, rectum, and sigmoid, the agreement of D0.1cc, D1cc, and D2cc were within a 0.78% level. Conclusions With minimal human-computer interactions, the DVS can verify the accuracy of doses calculated by the TPS.
- Published
- 2018
8. Image guided radiation therapy boost in combination with high-dose-rate intracavitary brachytherapy for the treatment of cervical cancer
- Author
-
Pei Wang, Xianliang Wang, Bin Wan, Gang Yin, Ke Yuan, and Jie Li
- Subjects
HDR brachytherapy ,cervical cancer ,medicine.medical_treatment ,Brachytherapy ,Rectum ,lcsh:Medicine ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,External beam radiotherapy ,Prospective cohort study ,IGRT ,Image-guided radiation therapy ,Cervical cancer ,Original Paper ,medicine.diagnostic_test ,business.industry ,Equivalent dose ,lcsh:R ,Magnetic resonance imaging ,medicine.disease ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Nuclear medicine ,business - Abstract
Purpose : The purpose of this study was to demonstrate the dosimetric and clinical feasibility of image guided radiation therapy (IGRT) combined with high-dose-rate (HDR) intracavitary brachytherapy (ICBT) to improve dose distribution in cervical cancer treatment. Material and methods: For 42 cervical cancer patients, magnetic resonance imaging (MRI) scans were acquired after completion of whole pelvic irradiation 45-46 Gy and 5 fractions of B + I (ICBT + IGRT) treatment were subsequently received. The high risk clinical target volume (HRCTV), intermediate risk clinical target volume (IRCTV), bladder, rectum, and sigmoid were contoured on the computed tomography (CT) scans. The total planning aim doses for HRCTV was D 90% > 85 Gy, whilst constraints for rectum and sigmoid were D 2cc < 75 Gy and D 2cc < 90 Gy for bladder in terms of an equivalent dose in 2 Gy (EQD2) for external beam radiotherapy (EBRT) and brachytherapy boost. The IGRT plan was optimized on top of the ICBT dose distribution. A dosimetric comparison was made between B + I and optimized ICBT (O-ICBT) only. Results: The mean D 90% of HRCTV was comparable for B + I and O-ICBT (p = 0.82). For B + I plan, HRCTV D100%, IRCTV D 100% , and IRCTV D 90% were significantly increased by a mean of 10.52 Gy, 5.61 Gy, and 2.70 Gy, respectively (p < 0.01). The D 2cc for bladder, rectum, and sigmoid were lower by a mean of 21.36, 6.78, and 10.65 Gy, respectively (p < 0.01). The mean rectum V60 Gy value over 42 patients was almost the same for both techniques but for bladder and sigmoid B + I had higher V60 Gy mean values as compared with the O-ICBT. Conclusions : B + I can improve dose distribution in cervical cancer treatment; it could be useful for tumors extended beyond the reach of intracavitary/interstitial brachytherapy (IC/ISBT) or for centers that are inexperienced or ill-equipped with IC/ISBT techniques. Additional confirmatory prospective studies with larger numbers of patients and longer follow-up are required to validate the durability.
- Published
- 2015
9. Dosimetric study for cervix carcinoma treatment using intensity modulated radiation therapy (IMRT) compensation based on 3D intracavitary brachytherapy technique.
- Author
-
Gang Yin, Pei Wang, Jinyi Lang, Yin Tian, Yangkun Luo, Zixuan Fan, and Kin Yip Tam
- Subjects
- *
CERVICAL cancer treatment , *RADIOISOTOPE brachytherapy , *CANCER radiotherapy , *INTENSITY modulated radiotherapy , *RADIATION dosimetry - Abstract
Purpose: Intensity modulated radiation therapy (IMRT) compensation based on 3D high-dose-rate (HDR) intracavitary brachytherapy (ICBT) boost technique (ICBT + IMRT) has been used in our hospital for advanced cervix carcinoma patients. The purpose of this study was to compare the dosimetric results of the four different boost techniques (the conventional 2D HDR intracavitary brachytherapy [CICBT], 3D optimized HDR intracavitary brachytherapy [OICBT], and IMRT-alone with the applicator in situ). Material and methods: For 30 patients with locally advanced cervical carcinoma, after the completion of external beam radiotherapy (EBRT) for whole pelvic irradiation 45 Gy/25 fractions, five fractions of ICBT + IMRT boost with 6 Gy/fractions for high risk clinical target volume (HRCTV), and 5 Gy/fractions for intermediate risk clinical target volume (IRCTV) were applied. Computed tomography (CT) and magnetic resonance imaging (MRI) scans were acquired using an in situ CT/MRI-compatible applicator. The gross tumor volume (GTV), the high/intermediate-risk clinical target volume (HRCTV/IRCTV), bladder, rectum, and sigmoid were contoured by CT scans. Results: For ICBT + IMRT plan, values of D90, D100 of HRCTV, D90, D100, and V100 of IRCTV significantly increased (p < 0.05) in comparison to OICBT and CICBT. The D2cc values for bladder, rectum, and sigmoid were significantly lower than that of CICBT and IMRT alone. In all patients, the mean rectum V60 Gy values generated from ICBT + IMRT and OICBT techniques were very similar but for bladder and sigmoid, the V60 Gy values generated from ICBT + IMRT were higher than that of OICBT. For the ICBT + IMRT plan, the standard deviations (SD) of D90 and D2cc were found to be lower than other three treatment plans. Conclusions: The ICBT + IMRT technique not only provides good target coverage but also maintains low doses (D2cc) to the OAR. ICBT + IMRT is an optional technique to boost parametrial region or tumor of large size and irregular shape when intracavitary/interstitial brachytherapy cannot be used. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
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