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Start Over Author "T. Heinonen" Journal journal of computer assisted tomography
4 results on '"T. Heinonen"'

1. Computed Tomography-Based Tumor Volume in Non-Hodgkin Lymphoma

Author

Seppo Soimakallio, Ritva Järvenpää, T. Heinonen, Sylvia Rautakunnas, Tiina Luukkaala, Prasun Dastidar, Pirkko-Liisa Kellokumpu-Lehtinen, Hannu Eskola, Maija Rossi, and Hannu Pertovaara

Subjects
Male, medicine.medical_specialty, Lymphoma, B-Cell, Iohexol, Contrast Media, Computed tomography, Malignancy, Clinical correlation, Computed tomographic, Imaging, Three-Dimensional, Image Processing, Computer-Assisted, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, medicine.diagnostic_test, business.industry, Reproducibility of Results, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Survival Analysis, Tumor Burden, Lymphoma, Radiographic Image Enhancement, Treatment Outcome, Hodgkin lymphoma, Female, Radiology, Tomography, X-Ray Computed, business, Nuclear medicine, Follow-Up Studies, Volume (compression)
Abstract

Objectives: To evaluate the prognostic significance of tumor volume in computed tomographic (CT) images of non-Hodgkin lymphoma patients. To compare CT volumes with those measured by magnetic resonance imaging (MRI). Methods: Twenty-five patients with B cell-type non-Hodgkin lymphoma (16 men, 9 women, age range, 48-77 years) were imaged with CT at 5 time points. The volumes and volume reductions were associated with clinical characteristics and treatment outcome. The CT-derived tumor volumes were correlated with MRI volumes derived earlier for the same patients. Results: Good agreement was found between 1-dimensional (1D), 2D, and 3D analyses. The CT-derived median tumor volumes were 306 cm 3 , 174 cm 3 , 75 cm 3 , 28 cm 3 , and 15 cm 3 at the 5 time points. These volumes were found to associate, for example, with mortality and tumor malignancy. The CT-based tumor volumes showed good correlation with MRI. Conclusions: Tumor volume quantification is a powerful tool that associates with clinical characteristics and treatment outcome.

Published
2009

2. Response analysis of non-hodgkin lymphoma using magnetic resonance imaging-based volumes

Author

Maija Rossi, Seppo Soimakallio, Sylvia Rautakunnas, Pirkko-Liisa Kellokumpu-Lehtinen, Ritva Järvenpää, T. Heinonen, Tiina Luukkaala, Prasun Dastidar, Hannu Pertovaara, and Hannu Eskola

Subjects
Adult, Lymphoma, B-Cell, medicine.medical_treatment, Antineoplastic Agents, Sensitivity and Specificity, Young Adult, Text mining, Imaging, Three-Dimensional, immune system diseases, hemic and lymphatic diseases, Image Interpretation, Computer-Assisted, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, Young adult, Aged, Semiautomatic segmentation, Chemotherapy, medicine.diagnostic_test, business.industry, Reproducibility of Results, Magnetic resonance imaging, Middle Aged, medicine.disease, Image Enhancement, Prognosis, Magnetic Resonance Imaging, Lymphoma, Treatment Outcome, Hodgkin lymphoma, business, Nuclear medicine
Abstract

Objective: The aim of this study was to determine the volume of non―Hodgkin lymphomas (NHLs) using semiautomatic segmentation and to correlate these results with clinical findings, treatment, and prognosis in patients with B-cell―type NHL. Methods: For this study, 29 patients with NHL underwent magnetic resonance imaging at 5 time points after onset of disease. Volumetric analysis of the tumors was accomplished with semiautomatic segmentation by the Anatomatic software. Results: The median tumor volumes from the first to the fifth examination were 468, 256, 90, 38, and 33 cm 3 . Good correlation with 1-dimensional and 2-dimensional measures, used as standard methods in response categorization, was found. Surprisingly, volume reductions in excess of 239 cm 3 after only 1 week of chemotherapy decreased the survival probability. Conclusions: Volume measurements seem to be highly informative for prognosis in the very early stages of treatment for patients with NHL.

Published
2009

3. Computed tomography-based tumor volume in non-Hodgkin lymphoma: clinical correlation and comparison with magnetic resonance imaging.

Author

Rossi M, Pertovaara H, Dastidar P, Järvenpää R, Luukkaala T, Rautakunnas S, Heinonen T, Eskola H, Soimakallio S, and Kellokumpu-Lehtinen PL

Subjects
Aged, Contrast Media, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted methods, Imaging, Three-Dimensional methods, Iohexol, Lymphoma, B-Cell drug therapy, Male, Middle Aged, Radiographic Image Enhancement methods, Reproducibility of Results, Survival Analysis, Treatment Outcome, Lymphoma, B-Cell diagnostic imaging, Lymphoma, B-Cell pathology, Magnetic Resonance Imaging methods, Tomography, X-Ray Computed methods, Tumor Burden
Abstract

Objectives: To evaluate the prognostic significance of tumor volume in computed tomographic (CT) images of non-Hodgkin lymphoma patients. To compare CT volumes with those measured by magnetic resonance imaging (MRI)., Methods: Twenty-five patients with B cell-type non-Hodgkin lymphoma (16 men, 9 women, age range, 48-77 years) were imaged with CT at 5 time points. The volumes and volume reductions were associated with clinical characteristics and treatment outcome. The CT-derived tumor volumes were correlated with MRI volumes derived earlier for the same patients., Results: Good agreement was found between 1-dimensional (1D), 2D, and 3D analyses. The CT-derived median tumor volumes were 306 cm, 174 cm, 75 cm, 28 cm, and 15 cm at the 5 time points. These volumes were found to associate, for example, with mortality and tumor malignancy. The CT-based tumor volumes showed good correlation with MRI., Conclusions: Tumor volume quantification is a powerful tool that associates with clinical characteristics and treatment outcome.

Published
2009
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4. Response analysis of non-hodgkin lymphoma using magnetic resonance imaging-based volumes.

Author

Rossi M, Dastidar P, Pertovaara H, Järvenpää R, Luukkaala T, Kellokumpu-Lehtinen PL, Rautakunnas S, Heinonen T, Soimakallio S, and Eskola H

Subjects
Adult, Aged, Humans, Image Enhancement methods, Middle Aged, Prognosis, Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome, Young Adult, Antineoplastic Agents therapeutic use, Image Interpretation, Computer-Assisted methods, Imaging, Three-Dimensional methods, Lymphoma, B-Cell diagnosis, Lymphoma, B-Cell therapy, Magnetic Resonance Imaging methods
Abstract

Objective: The aim of this study was to determine the volume of non-Hodgkin lymphomas (NHLs) using semiautomatic segmentation and to correlate these results with clinical findings, treatment, and prognosis in patients with B-cell-type NHL., Methods: For this study, 29 patients with NHL underwent magnetic resonance imaging at 5 time points after onset of disease. Volumetric analysis of the tumors was accomplished with semiautomatic segmentation by the Anatomatic software., Results: The median tumor volumes from the first to the fifth examination were 468, 256, 90, 38, and 33 cm. Good correlation with 1-dimensional and 2-dimensional measures, used as standard methods in response categorization, was found. Surprisingly, volume reductions in excess of 239 cm after only 1 week of chemotherapy decreased the survival probability., Conclusions: Volume measurements seem to be highly informative for prognosis in the very early stages of treatment for patients with NHL.

Published
2009
Full Text
View/download PDF

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