1. Diagnostic Impact of Quantitative Dual-Energy Computed Tomography Perfusion Imaging for the Assessment of Subsegmental Pulmonary Embolism
- Author
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Serife Bozbas, Hakkı Tankut Akay, Gokhan Kahraman, Pinar Celtikci, Bahadır Gültekin, and Koray Hekimoglu
- Subjects
Adult ,Male ,Computed Tomography Angiography ,Perfusion Imaging ,Perfusion scanning ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,medicine ,Computed Tomography Perfusion Imaging ,Humans ,Radiology, Nuclear Medicine and imaging ,Thrombus ,Computed tomography angiography ,Aged ,Retrospective Studies ,Aged, 80 and over ,Lung ,medicine.diagnostic_test ,business.industry ,Dual-Energy Computed Tomography ,respiratory system ,Middle Aged ,medicine.disease ,Pulmonary embolism ,medicine.anatomical_structure ,Normal lung ,Radiographic Image Interpretation, Computer-Assisted ,Female ,business ,Nuclear medicine ,Pulmonary Embolism ,030217 neurology & neurosurgery - Abstract
OBJECTIVE The aim of this study was to investigate the quantitative differences of dual-energy computed tomography perfusion imaging measurements in subsegmental pulmonary embolism (SSPE), between normal lung parenchyma (NLP) and hypoperfused segments (HPS) with and without thrombus on computed tomography angiography (CTA). METHODS Lung attenuation, iodine density, and normalized uptake values were measured from HPS and NLP on iodine maps of 43 patients with SSPE. Presence of pulmonary embolism (PE) on CTA was recorded. One-way repeated-measures analysis of variance and Kruskal-Wallis analyses with post hoc comparisons were conducted. RESULTS The numbers of HPS with and without SSPE on CTA were 45 (55.6%) and 36 (44.4%), respectively. Lung attenuation of NLP was significantly different from HPS (P < 0.001). Iodine density and normalized uptake values of HPS with PE were significantly lower than those of HPS without PE, which is significantly lower than NLP (P < 0.001). CONCLUSIONS Subsegmental pulmonary embolism causes HPS on dual-energy computed tomography perfusion imaging, which demonstrates different iodine density and normalized uptake values depending on the presence of thrombus.
- Published
- 2020