1. Effect of the algal alkaloid caulerpin on neuropeptide Y (NPY) expression in the central nervous system (CNS) of Diplodus sargus
- Author
-
Frederico Almada, Laura Magliozzi, Ernesto Mollo, Anna Di Cosmo, Gianluca Polese, Valeria Maselli, Magliozzi, Laura, Maselli, Valeria, Almada, Frederico, Di Cosmo, Anna, Mollo, Ernesto, and Polese, Gianluca
- Subjects
Indoles ,Physiology ,030310 physiology ,Central nervous system ,Zoology ,Diplodus sargus ,Endogeny ,NPY ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,medicine ,Animals ,Neuropeptide Y ,14. Life underwater ,Biological invasions ,Caulerpin ,Ecology, Evolution, Behavior and Systematics ,0303 health sciences ,Behavior, Animal ,biology ,Alkaloid ,Brain ,Diplodus ,Caulerpa cylindracea ,Neuropeptide Y receptor ,biology.organism_classification ,Sea Bream ,Food web ,Diet ,medicine.anatomical_structure ,Animal Science and Zoology ,Diplodus sargu ,Biological invasion ,030217 neurology & neurosurgery ,Sargus - Abstract
Recent studies have suggested that Mediterranean indigenous fish species are affected by bioactive metabolites coming from marine invasive species via food web interactions. In particular, both physiological and behavioural changes in the white sea bream Diplodus sargus were related to caulerpin (CAU), a bisindolic alkaloid particularly abundant in the invasive alga Caulerpa cylindracea, on which the fish actively feed. Dietary administration of CAU decreased aggressiveness in D. sargus, suggesting an anxiolytic-like effect of CAU possibly mediated by endogenous anxiolytic agents. This hypothesis is supported here by the finding of a significant increase of NPY transcriptional expression in the brain of fish fed with CAU enriched food, shedding more light on the neural mechanisms behind the altered behaviour of D. sargus. Fundação para a Ciência e a Tecnologia - FCT; FEDER info:eu-repo/semantics/publishedVersion
- Published
- 2019
- Full Text
- View/download PDF