Search

Your search keyword '"Sher PM"' showing total 1 results
Start Over Author "Sher PM" Journal journal of combinatorial chemistry

Refine your results

1 results on '"Sher PM"'

1. Addition of benzylic and allylic organozinc and Grignard reagents to resin-bound imines to provide alpha-branched secondary amines bearing a wide variety of functional groups. Utility in the synthesis of beta-3 adrenergic receptor agonists.

Author

Wu G, Cai ZW, Bednarz MS, Kocy OR, Gavai AV, Godfrey JD Jr, Washburn WN, Poss MA, and Sher PM

Subjects
Adrenergic beta-Agonists chemistry, Combinatorial Chemistry Techniques, Molecular Structure, Structure-Activity Relationship, Adrenergic beta-3 Receptor Agonists, Adrenergic beta-Agonists chemical synthesis, Amines chemistry, Benzene chemistry, Imines chemistry, Zinc chemistry
Abstract

Benzylic and allylic organozinc and Grignard reagents have been added to resin-bound imines to provide alpha-branched secondary amines. Many functional groups, including electrophilic groups, were compatible with this methodology. Three modules--a resin-bound primary amine, an aromatic aldehyde, and the organometallic--were independently varied to produce a combinatorial library of alpha-branched secondary amines designed as beta-3 adrenergic receptor agonists.

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results