1,109 results on '"Neto AT"'
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2. Therapeutic Drug Monitoring in Inflammatory Bowel Disease
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Manoel Alvaro de Freitas Lins Neto, João Otávio Moraes Rolim, Diogo César Maurício de Oliveira Jatobá, Júnia Elisa Carvalho de Meira, Luís Henrique Salvador Filho, Lucas Correia Lins, and Jorge Artur Coelho Peçanha
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infliximab antibody ,infliximab ,drug monitoring ,therapeutic drug ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Inflammatory bowel disease (IBD) is a problem that directly affects the quality of life of patients suffering from this condition. Monitoring the serum level of infliximab (IFX) (TDM) is an important tool for guiding therapeutic decisions in IBD patients. The purpose of this study was to determine the significance of quantitatively measuring the serum level of IFX (TDM) and antibody to IFX (ATI). Methods and materials: Prospective observational study involving 40 IBD patients on IFX therapy, including 14 Proactive (week 06 of the induction phase) and 26 Reactive (maintenance phase). Immediately prior to the infusion, blood samples were drawn and measured using a Bulhlmann rapid test instrument. Serum concentrations of IFX were categorized as supratherapeutic (>7.0 micrograms/ml), therapeutic (between 3.0 and 7.0 micrograms/ml), and subtherapeutic (3.0 micrograms/ml). When the serum concentration of IFX was 3 mcg/ml (subtherapeutic), the ATI was measured. 25 patients with CD and 15 patients with UC were evaluated. Only three of the twenty patients with subtherapeutic serum levels had a positive ATI, and both were reactive; two had CD and one had UC. There was a statistically significant difference between reactive and proactive patients with respect to levels of CRP (p = 0.042), with proactive DNS patients suffering greater alterations in CRP and albumin.
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- 2023
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3. Injection of Freshly Collected Adipose Tissue for the Treatment Complex Cryptoglandular Anal Fistula: Case Report
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Daniel Mauricio Londoño Estrada, Cristiane Koizimi Martos Fernandes, Marina Barbarela Grisolia de Oliveira, Gustavo Moreira Costa de Souza, Paulo Rocha França-Neto, Fábio Lopes de Queiroz, and Antônio Lacerda-Filho
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cryptoglandular ,Fistula-in-ano ,perianal fistula ,freshly collected adipose tissue ,adipose-derived stem cell ,stem cell therapy ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction Perianal fistula is a common colorectal disease which is caused mainly by cryptoglandular disease. Although most cases are treated successfully by surgery, management of complex perianal fistulas (CPAF) remains a challenge with limited results in recurrence and sometimes associated with fecal incontinence. The CPAF treatment with autologous adipose-derived mesenchymal stem cells (ASCs) had become a research hotspot. The technique started to be used in the treatment of Crohn's disease (CD) fistulas, where the studies showed safe and goods result from the procedure. Cultured ASCs have been used but this approach requires the preceding collection of adipose tissue, time for isolation of ASCs and subsequent in vitro expansion, need for laboratory facilities, and expertise in cell culturing. These factors have been getting over by using the commercially available alternative, allogenic ASCs. Treatment with allogeneic ASCs has shown good results in patients with CD fistulas, however with the disadvantage of being expensive. Objective To show that the injection with freshly collected adipose tissue is an alternative to treatment with autologous or allogenic ASCs with several advantages. Methods: In this case report, we show our first experience in the treatment of CPAF with the application of collected adipose tissue in a tertiary referral hospital from Belo Horizonte, Brazil. Results The patient had a good postoperative recuperation with a complete fistula healing after 8 months without adverse effects. Conclusion Injection with freshly collected adipose tissue is a promising and apparently safe sphincter-sparing technique in the treatment of CPAF.
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- 2023
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4. Incidence of Intestinal Constipation During the COVID-19 Pandemic Period in Medical Students from a Private Institution in São Paulo, SP
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Isaac José Felippe Corrêa Neto, Alisson de Lucena Silva, Renato Cardoso de Melo Tajiri, Cláudia Theis, Gabriela Schelle, Rodrigo Ambar Pinto, Victor Keniti Gomes Nishiyama, and Laercio Robles
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chronic intestinal constipation ,coronavirus pandemic ,medical students ,rome criteria ,feces consistency ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction Chronic intestinal constipation (CIC) presents an incidence of 2.6 to 30.7% in the overall population and due to the social reality imposed by the coronavirus pandemic, some behavior changes in the Brazilian population occurred that might or not be associated with alterations of CIC prevalence. Objective To assess CIC incidence in medical students before and during the COVID-19 pandemic in Brazil in a private higher educational institution in the city of São Paulo, state of São Paulo. Methods Clinic data were collected through Google Forms software from the same students seeking to analyze the variables before (year of 2019) and during the coronavirus pandemic. The data were: age, sex, body mass index, constipation referred in a subjective way and confirmed through the ROME III criteria, feces consistency and anxiety and/or depression during the pandemic. Results A total of 126 medical students from a private higher education institution from São Paulo, SP were included. The average age was 22.9 years old, 70.6% were female and the average BMI was 23.3 kg/m2. Regarding the ROME III criteria, 32.5% presented > 2 in 2019 and 42.1% during the pandemic. Concerning the feces consistency, 31.75 and 35.71% presented dry Bristol 1 feces or in both periods, respectively. Conclusion It was observed an increase in the prevalence of chronic intestinal constipation in medical students from a private higher education institution from São Paulo, state of São Paulo, during the COVID-19 pandemic, as well as dryness in the feces.
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- 2023
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5. Watch and Wait, Worth It?
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Manoel Álvaro de Freitas Lins Neto, Luís Henrique Alves Salvador Filho, Jorge Artur Peçanha de Miranda Coelho, and João Otávio de Moraes Rolim
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rectum cancer ,neoadjuvant ,neoplasms ,colorectal surgery ,watch and wait ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background The surgery with total mesorectal excision recommended by R. J. Heald in 1982 is the gold standard. Rectal cancer (RC) surgery has a morbidity rate ranging from 6 to 35%, and it can cause functional issues such as sexual, urinary, and bowel dysfunction in the long term. Neoadjuvant chemoradiotherapy (CRT) has been gaining ground in patients with lesions in the middle and lower rectum. The aim of the present study is to present the experience of a reference service in the treatment of RC. Patients and Methods A retrospective study involving 53 patients diagnosed with RC between January 2017 and December 2019 with follow-up until December 2020. We examined tumor location, disease stage, digital rectal exam findings, carcinoembryonic antigen (CEA), therapeutic modality offered, and follow-up time. Results A total of 32% of the patients were men and 68% were women, with a mean age of 60 years old. Location: upper rectum in 6 cases, middle rectum in 21 cases, and lower rectum in 26 cases with evolution from 9.8 to 13.5 months. The most frequent complaints were hematochezia and constipation. A total of 36 patients underwent neoadjuvant therapy: 11 complete clinical response (CCR) (30.5%), 20 (55.5%) partial clinical response (PCR), and no response in 5 patients (14%). The follow-up ranged from 12 to 48 months, with a mean of 30.5 months. A total of 25% of the patients had RC that went beyond the mesorectal fascia, and 22.64% had metastases in other parts of the body when they were diagnosed. Conclusion Neoadjuvant radio and chemotherapy present themselves as an alternative in the treatment of rectal cancer. In 36 patients, 30.5% had a complete clinical response, 55.5% had a partial clinical response, and 14% had no response. It was worth doing the “Watch and Wait” (W&W) to sample. A definitive colostomy was avoided. However, it is necessary to expand the study to a larger follow-up and more patients. Additionally, it is necessary to implement a multicenter study.
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- 2022
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6. Does Prophylactic Use of Postcesarean Section Laxatives Favor Bowel Movements?
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Isaac José Felippe Corrêa Neto, Juliana Lazzarini Pizzo, Amanda Gambi Robles, Leonardo Mauri, and Laercio Robles
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constipation ,pregnancy ,cesarean delivery ,puerperium ,laxatives ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction Chronic constipation (CC) is a highly prevalent disease in Western society. Chronic constipation can have a different etiology in patients who underwent a cesarean section and result from postoperative stress and metabolic response to trauma, analgesic agents, immobilization, and dietary restrictions. Chronic constipation may also occur due to puerperium-related psychological changes and to the stretching and weakening of the perineal and abdominal muscles after childbirth. Objectives The present study analyzes intestinal transit restoration after a cesarean section and the influence of osmotic laxative agents. Methods The present prospective, nonrandomized sample study used the ROME III questionnaire and the Bristol stool scale in adult women who underwent a cesarean section. We divided the subjects into 2 groups, each with 30 patients, to compare the effect of the prophylactic administration of an osmotic laxative. Results We evaluated 60 randomly-chosen pregnant women from the Obstetrics ward of Hospital Santa Marcelina, São Paulo, SP, Brazil, from October 2019 to March 2020. Their mean age was 26.8 years old, and the mean gestation time was 37.95 weeks. Ten patients (16.7%) presented with constipation before the cesarean section, and 38 (63.3%) had a bowel movement after the procedure. However, in 84.2% of these patients, the usual stool consistency worsened. After the cesarean section, 46.7% of the women who did not receive laxative agents had a bowel movement, compared with 80% of those who did (p = 0.0074). Conclusion Some factors, including those related to the procedure, may hamper intestinal transit restoration after a cesarean section. Osmotic laxative agents can facilitate transit restoration with no negative effects in this group of patients.
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- 2022
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7. Study of defecation disorders in elderly patients
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Corrêa Neto, Isaac José Felippe, Mosca Neto, Mario, Lanfranchi, Vanessa Santos, Pedroso, Thales Ranieri, Figueiredo, Henrique Carvalho e Silva, Mocerino, Jéssica, Pascutti, Marcia, and Robles, Laercio
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- 2020
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8. Is There a Precise Correlation between the Lengths of the Peritoneal Reflection and the Middle Rectal Valve?
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Isaac José Felippe Corrêa Neto, Mariana Campello de Oliveira, Laercio Robles, Leonardo Marcos Lopes Santos, Alexander Sá Rolim, Rogério Freitas Lino Souza, Hugo Henriques Watté, and Angelo Rossi da Silva Cecchini
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peritoneal reflection ,rectal valve ,rigid sigmoidoscopy ,obesity ,parity ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction Pelvic anatomy remains a challenge, and thorough knowledge of its intricate landmarks has major clinical and surgical implications in several medical specialties. The peritoneal reflection is an important landmark in intraluminal surgery, rectal trauma, impalement, and rectal adenocarcinoma. Objectives To investigate the correlation between the lengths of the middle rectal valve and of the peritoneal reflection determined with rigid sigmoidoscopy and to determine whether there are any differences in the location of the peritoneal reflection between the genders and in relation to body mass index (BMI) and parity. Design We prospectively investigated the location of the middle rectal valve and of the peritoneal reflection via intraoperative rigid sigmoidoscopy in colorectal cancer patients undergoing elective colorectal surgery. Results We evaluated 38 patients with a mean age of 55.5 years old (57.5% males) who underwent colorectal surgery at the coloproctology service of the Hospital Santa Marcelina, São Paulo, state of São Paulo, Brazil. There was substantial agreement between the lengths of the middle rectal valve and of the peritoneal reflection (Kappa = 0.66). In addition, the peritoneal reflection was significantly lower in overweight patients (p = 0.013 for women and p 2 vaginal deliveries (p = 0.009), but there was no significant difference in the length of the peritoneal reflection between genders (p = 0.32). Conclusion There was substantial agreement between the lengths of the peritoneal reflection and of the middle rectal valve, and the peritoneal reflection was significantly lower in overweight patients and in women with more than two vaginal deliveries.
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- 2022
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9. The Importance of the Therapeutic Care Plan in Colorectal Surgery
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Henrique Carvalho e Silva Figueiredo, Isaac José Felippe Corrêa Neto, Jéssica Mocerino, Mariana Campello de Oliveira, and Laercio Robles
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therapeutic plan ,risk management ,colorectal surgery ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction A therapeutic plan is elaborated based on the health needs of each user, allowing a multidisciplinary team to assess diagnoses, treatment options, bonds, and optimal hospitalization time. Objectives To identify risk management tools already used and implemented in a reference teaching hospital in the city of São Paulo and to analyze their application and risk factors in medium and large colorectal surgery. Method Observational, longitudinal, and prospective study, with 30 patients with colorectal disease hospitalized in the surgical ward of the coloproctology service and in need of surgical treatment. In the first group, the protocol was applied with the knowledge of the researcher only, and, in the second group, with the knowledge of both the researcher and the attending physicians. Results Sixty percent of the patients were female with a mean age of 60.93 years and body mass index (BMI) of 26.07 Kg/m2. After surgery, patients in the first group who did not receive venous thromboembolism (VTE) prophylaxis in the first 24 hours had an increased risk of having the event compared with those who returned to prophylaxis (p
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- 2021
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10. Tailgut Cyst – A Case Report
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Bruno Lorenzo Scolaro, Gustavo Becker Pereira, Fangio Ferrari, Letícia Dall'Agnol, Lívia de Aragon Arias, and Anisio de Souza Neto
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pelvic neoplasms ,cysts ,congenital abnormalities ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Retrorectal hamartoma, also called tailgut cyst, is a congenital lesion resulting from the non-regression of embryo remnants of the hindgut. We describe in this work the case report of a 68-year-old man, previously healthy, complaining of rectal bulging for 4 months, which was diagnosed by nuclear magnetic resonance imaging as a multiloculated and mucinous lesion, suggestive of tailgut cyst. In view of the finding, the lesion was surgically resected, due to the potential for future complications, and, through the anatomopathological analysis, there were no findings of malignancy in the specimen.
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- 2022
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11. Study of defecation disorders in elderly patients
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Isaac José Felippe Corrêa Neto, Mario Mosca Neto, Vanessa Santos Lanfranchi, Thales Ranieri Pedroso, Henrique Carvalho e Silva Figueiredo, Jéssica Mocerino, Marcia Pascutti, and Laercio Robles
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Distúrbios da evacuação ,Assoalho pélvico ,Idosos ,Incontinência anal ,Constipação intestinal ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Defecation disorders, whether anal incontinence or chronic intestinal constipation, are frequent pelvic floor alterations in the general population and are more common in those with risk factors,i.e., in the elderly, women with an obstetric background, and those with comorbidities, history of pelvic radiotherapy, diabetics, the bedridden, or those with history of orifice surgery, among others. Objective: To analyze the incidence of defecation disorders in geriatric patients treated at the Medical Specialties Outpatient Service (MSOS) of Hospital Santa Marcelina. Methods: Prospective, randomized study that interviewed the same patients in two moments: 1) subjective anamnesis through spontaneous history and 2) objective anamnesis with specific questionnaires to assess anal incontinence and chronic constipation. Results: Between March 2016 and June 2017, 149 patients were analyzed, of whom 114 (76.5%) were female, with a similar mean age between genders; 51.67% had symptoms of anal incontinence and/or chronic constipation. Only 35.5% of patients with complaints of fecal leakage or flatus spontaneously reported them, while 87.1% of constipated patients did so. In the present study, no significant correlation was observed between the mode of delivery (p = 0.106), pregnancy (p = 0.099), and the number of deliveries (p = 0.126) with anal incontinence. In turn, there was no higher incidence of chronic intestinal constipation in females (p = 0.099) and most patients with this complaint had Bristol type 1 or 2 stools. Conclusion: The incidence of defecation disorders in the geriatric population is high and, most notably, anal incontinence is not spontaneously reported by most patients. Resumo: Introdução: Os distúrbios da evacuação, seja a incontinência anal ou a constipação intestinal crônica, representam alterações do assoalho pélvico bastante frequente na população em geral e mais comumente naqueles com fatores de risco, ou seja, em idosos, mulheres com passado obstétrico, comorbidades, antecedente de radioterapia pélvica, diabéticos, acamados, história de cirurgias orificiais, dentre outros. Objetivo: Analisar a incidência de distúrbios defecatórios em pacientes geriátricos atendidos no Ambulatório de Especialidades Médicas (AME) do Hospital Santa Marcelina. Metodologia: Estudo prospectivo e aleatório com a entrevista do mesmo paciente em dois momentos: 1) Anamnese subjetiva através da história espontânea e 2) Anamnese objetiva com questionários específicos para avaliação de incontinência anal e constipação intestinal crônica. Resultados: Foram analisados 149 pacientes entre Março de 2016 e Junho de 2017, sendo 114 (76,5%) do sexo feminino com média de idade semelhante entre os sexos; 51,67% apresentavam sintomas de incontinência anal e/ou constipação intestinal crônica. Apenas 35,5% dos pacientes com queixas de escape de fezes ou flatos relataram de forma espontânea e 87,1% dos pacientes constipados o fizeram. No presente estudo não se verificou correlação significativa entre via de parto p = 0,106, gestação p = 0,099 e número de partos p = 0,126 com incontinência anal. Por outro lado, não se verificou maior incidência de constipação intestinal crônica no sexo feminino p = 0,099 e a maioria dos pacientes com essa queixa apresentavam fezes ressecadas tipo Bristol 1 ou 2. Conclusão: Incidência de distúrbios da defecação na população geriátrica é elevada e, notadamente a IA não é referida de forma espontânea pela maioria dos pacientes.
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- 2020
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12. Epidemiological study on Fournier syndrome in a tertiary hospital in Jundiaí-SP from October 2016 to October 2018†
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Inácio, Mariana Fernandes, Lima, Renato Pierre, Neto, Sebastião Rizzo, Lopes, Felipe Andrade, Pantaroto, Mário, and de Sousa, Alexandre Venâncio
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- 2020
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13. Tansanal total mesorectal excision (TaTME): systematization and mediated results in 10 patients
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Neiva, Guilherme Inácio Bertoldo de Melo e Patriarca da Silva, Soares, Fábio Alves, Silva, Silvana Marques e, Viana, Pedro Wilson Diniz, Neto, Mário Nóbrega de Araújo, Oliveira, Olane Marquez de, and Nascimento, Mauricio Cotrim
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- 2020
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14. Perforated acute abdomen in a patient with COVID-19: an atypical manifestation of the disease
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Isaac José Felippe Corrêa Neto, Kaline Fortes Viana, Milena Braga Soares da Silva, Leandro Mariano da Silva, Gustavo de Oliveira, Angelo Rossi da Silva Cecchini, Alexander Sá Rolim, and Laercio Robles
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Coronavírus, COVID, Pneumotórax, Pneumoperitônio ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: The Coronavirus belongs to a family of RNA viruses that can cause respiratory infection, with the possibility of gastrointestinal manifestations in approximately 5–50% of the cases. Objective: To report a surgical case with a diagnosis of COVID-19 that developed acute perforated abdomen and pneumothorax. Case report: This was an 80-year-old female patient with respiratory symptoms, with dry cough and fever and diffuse abdominal pain with signs of peritonitis. She had leukocytosis, kidney dysfunction and an increase in D-dimer with positive PCR for COVID. Computed tomography of the chest and abdomen showed pneumothorax on the right and extensive pneumoperitoneum. Conclusion: The presentation of COVID-19 with severe pulmonary and abdominal complications requires specialized and emergency treatments, but it has high mortality rates. Resumo: Introdução: O coronavírus pertence a uma família de vírus RNA que pode causar infecção respiratória com possibilidade de manifestações gastrintestinais em torno de 5% a 50% dos casos. Objetivo: Relatar caso operado com diagnóstico de COVID-19 e evolução com abdome agudo perfurativo e pneumotórax. Relato do caso: Paciente do sexo feminino de 80 anos com sintomas respiratórios com tosse seca e febre e dor abdominal difusa com sinais de peritonite. Apresentava leucocitose, disfunção renal e aumento de D-dímero com PCR positivo para COVID. Tomografia computadorizada de tórax e abdome demonstrando pneumotórax à direita e extenso pneumoperitônio. Conclusão: A apresentação do COVID-19 com sérias complicações pulmonar e abdominal requer tratamentos especializados e em regime de emergência, entretanto com altas taxas de mortalidade.
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- 2020
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15. Epidemiological study on Fournier syndrome in a tertiary hospital in Jundiaí-SP from October 2016 to October 2018†
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Mariana Fernandes Inácio, Renato Pierre Lima, Sebastião Rizzo Neto, Felipe Andrade Lopes, Mário Pantaroto, and Alexandre Venâncio de Sousa
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Fournier’s gangrene is a polymicrobial infection caused by aerobic and anaerobic microorganisms, which determine a fast and progressive necrotizing fasciitis, compromising mainly the perineal region and the genital region, being able to evolve to sepsis, multiple organ failure and death. Treatment consists of early surgical diagnosis and debridement, associated with broad-spectrum antibiotic therapy and hyperbaric oxygen therapy. Objective: Compare the most prevalent epidemiological data of patients with Fournier's Syndrome with the data examined in the literature in order to evaluate the incidence in the analyzed service, treatment form and evolution of the patients with the disease. Materials and methods: Observational transversal study from the medical records of patients diagnosed with the disease at the São Vicente de Paulo Charity Hospital in Jundiaí, SP, from October 2016 to October 2018. Results: 23 patients with Fournier’s Syndrome, all included in the study, and were analyzed. The most prevalent epidemiological data on the disease, such as age, sex, association with other comorbidities, treatment performed, mortality and early surgical procedure, had obtained a similar data as compared as the medical literature that was in studied. Conclusion: Despite the recognized severity of Fournier’s Syndrome, early diagnosis combined with extensive surgical debridement, broad-spectrum antibiotic therapy and measures and oxygen therapy when available are important measures to contain the rapid progression of the disease, thus decreasing its levels of mortality. Resumo: Introdução: A Gangrena de Fournier é uma infecção polimicrobiana ocasionada por microrganismos aeróbios e anaeróbios, que determinam uma fascite necrosante rápida e progressiva, comprometendo principalmente a região do períneo e a região genital, podendo evoluir para sepse, falência de múltiplos órgãos e óbito. O tratamento consiste no diagnóstico e desbridamento cirúrgico precoce, associado à antibioticoterapia de largo espectro e oxigenoterapia hiperbárica. Objetivo: Comparar dados epidemiológicos mais prevalentes dos pacientes diagnosticados com Síndrome de Fournier com os dados já descritos na literatura a fim de avaliar a incidência no serviço em questão analisado, forma de tratamento e evolução dos pacientes com a doença. Materiais e métodos: Estudo transversal observacional a partir da análise de prontuários de pacientes diagnosticados com a doença no Hospital de Caridade São Vicente de Paulo de Jundiaí-SP, no período entre Outubro de 2016 a Outubro de 2018. Resultados: Foram analisados 23 pacientes com diagnóstico de Síndrome de Fournier, todos incluídos na pesquisa. Avaliado os dados epidemiológicos mais prevalentes na doença, como faixa etária, sexo, associação com outras comorbidades, tratamento realizado, mortalidade decorrente da doença, período médio de internação, uso de antibioticoterapia e necessidade de procedimento cirúrgico, obtendo-se dados semelhantes com os já descritos na literatura médica. Conclusão: Apesar da reconhecida gravidade da Síndrome de Fournier, o diagnóstico precoce aliado ao desbridamento cirúrgico extenso, antibioticoterapia de amplo espectro e medidas e oxigenioterapia quando disponível são medidas importantes na contenção da rápida progressão da doença, diminuindo assim seus níveis de mortalidade. Keywords: Fournier gangrene, Debridement, Antibiotic prophylaxis, Palavras-chave: Gangrena de Fournier, Desbridamento, Antibioticoprofilaxia
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- 2020
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16. Tansanal total mesorectal excision (TaTME): systematization and mediated results in 10 patients
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Guilherme Inácio Bertoldo de Melo e Patriarca da Silva Neiva, Fábio Alves Soares, Silvana Marques e Silva, Pedro Wilson Diniz Viana, Mário Nóbrega de Araújo Neto, Olane Marquez de Oliveira, and Mauricio Cotrim Nascimento
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: Transanal total mesorectal excision is a surgical technique for minimally invasive resection of the rectum and perirectal tissues. It is indicated for patients with medial and distal rectum cancer confined to the mesorectal envelope. This study describes a series of patients undergoing transanal total mesorectal excision. Methods: Ten patients were selected to undergo transanal total mesorectal excision using the SILS-Port® platform. All patients included here had middle or low rectal cancer. Abdominal access for proximal colon mobilization was performed by laparoscopy in all cases. As a rule, in 9 of the 10 cases, the surgical specimen was removed transanally. Results: During a 41-month period, 10 patients underwent transanal total mesorectal excision based on curative intent. The first indication for transanal total mesorectum excision was medial and distal rectal cancer, locally invasive and confined to the mesortal envelope. The median age of patients with rectal cancer at the time of surgery was 61 years (mean 59.4 years, range 22–78 years), with 80% (8) female and 20% (2) male. The median surgical time was 305′ (mean 314′, range 260‒420′). The median postoperative length of stay was five days (average of 7.3 days, interval of 3–23 days). There was no postoperative mortality. Surgical complications included postoperative ileus (n = 1), bladder paresis (n = 1), and ileostomy stenosis (n = 1). All patients had negative surgical margins for neoplasia and more than 12 resected lymph nodes. The tumors were between 1 and 9 cm from the anal margin. Conclusion: Total transanal mesorectal excision has been shown to be a viable method for oncologic resection of locally advanced rectal cancer with curative intent. Resumo: Contexto: A excisão total do mesorreto por via transanal é uma aborgadem crânio-caudal para a realização de ressecção minimamente invasiva do reto e tecidos perirretais em monobloco. É adequada para pacientes com câncer de reto médio e distal confinados ao envelope mesorretal. Aqui relatamos uma série de pacientes submetidos à excisão total do mesorreto por via transanal. Métodos: Dez pacientes foram selecionados para serem submetidos à excisão total do mesorreto por via transanal utilizando a plataforma SILS-Port®. Todos os pacientes eram portadores de câncer retal de localização extraperitoneal. O acesso abdominal para mobilização do cólon proximal, em todos os casos, foi realizado por laparoscopia. Como regra, a retirada do espécime cirúrgico, em nove casos, ocorreu por via transanal. Resultados: Durante um período de 41 meses, 10 pacientes foram submetidos à excisão total do mesorreto por via transanal com intenção curativa. A indicação primária para excisão total do mesorreto transanal foi o câncer de reto médio e distal, localmente invasor, mas confinado ao envelope mesorretal. A mediana de idade dos pacientes com câncer de reto no momento da cirurgia foi de 61 anos (média de 59,4 anos, faixa de 22‒78 anos), sendo 80% (8) do sexo feminino e 20% (2) do sexo masculino. A mediana do tempo cirúrgico foi de 305’ (média de 314’, intervalo de 260‒420’). A mediana do tempo de permanência pós-operatória foi de cinco dias (média de 7,3 dias, intervalo de 3‒23 dias). Não houve mortalidade pós-operatória. As complicações cirúrgicas incluíram íleo paralítico (n = 1), paresia vesical (n = 1) e estenose de ileostomia (n = 1). Todos os pacientes tiveram margens cirúrgicas negativas para neoplasia e mais de 12 linfonodos ressecados. Os tumores distavam de 1 a 9 cm da margem anal. Conclusão: A excisão total do mesorreto transanal demonstrou-se um método viável para a ressecção oncológica de câncer de reto localmente avançado com intenção curativa. Keywords: TaTME, Total mesorectal excision, Rectal cancer, Colorectal surgery, Transanal surgery, Palavras-chave: TaTME, Excisão total do mesorreto, Cancer retal, Cirurgia colorretal, Cirurgia transanal
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- 2020
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17. Neoadjuvant radiotherapy in stage I cancer of the lower rectum
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dos Reis Neto, José Alfredo, dos Reis Junior, José Alfredo, Kagohara, Odorino Hideyoshi, Neto, Joaquim Simões, Banci, Sergio Oliva, Oliveira, Luciane Hiane, Espinoza, Gustavo Alejandro Gutierrez, and Alves Júnior, Antonio José Tiburcio
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- 2016
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18. Therapeutic Drug Monitoring in Inflammatory Bowel Disease
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Neto, Manoel Alvaro de Freitas Lins, additional, Rolim, João Otávio Moraes, additional, Jatobá, Diogo César Maurício de Oliveira, additional, de Meira, Júnia Elisa Carvalho, additional, Filho, Luís Henrique Salvador, additional, Lins, Lucas Correia, additional, and Peçanha, Jorge Artur Coelho, additional
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- 2023
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19. Injection of Freshly Collected Adipose Tissue for the treatment Complex Cryptoglandular Anal Fistula: Case Report
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Londoño Estrada, Daniel Mauricio, additional, Fernandes, Cristiane Koizimi Martos, additional, Oliveira, Marina Barbarela Grisolia de, additional, Souza, Gustavo Moreira Costa de, additional, Rocha França-Neto, Paulo, additional, Lopes de Queiroz, Fábio, additional, and Lacerda-Filho, Antônio, additional
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- 2023
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20. Mucocele of the vermiform appendix: diagnostic challenges and therapeutic approach
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Carlos Magno Queiroz da Cunha, Douglas Marques Ferreira de Lima, Giovanni Troiani Neto, Francisco Fernando Pimenta Lima, Caio Regis de Oliveira Medeiros Pimenta, and José Walter Feitosa Gomes
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Mucocele of the appendix is defined as the obstructive dilatation of the vermiform appendix by the abnormal accumulation of mucinous substance in its lumen. Imaging tests may be useful, but they commonly fail to evidence the etiology in question. Regarding the therapeutic approach, there are different options for treatment. Appendectomy was routinely used in simple cystadenomas, with good results. However, in cases of neoplasias, more aggressive resection is necessary, and the therapeutic course of choice is the right hemicolectomy. Case report: Patient presented to the surgery outpatient clinic with magnetic resonance imaging presenting an adnexal cyst of about 11.0 × 4.5 cm on the right. The patient had pain in the right iliac fossa for 6 months. Due to the radiological finding and persistence of the clinical picture, videolaparoscopy was performed, and an appendicular mass suggestive of mucocele was identified. A laparoscopic appendectomy was performed, with no signs of mucus extravasation. Histopathological analysis confirmed the diagnosis. Discussion: Mucocele is rarely diagnosed effectively in the preoperatively. In this context, imaging tests do rarely evidence such etiology. Given the importance of preoperative diagnosis for the definition of conduct, it is essential that this condition be always taken into account as a diagnostic hypothesis. Resumo: Introdução: A mucocele do apêndice é definida como a dilatação obstrutiva do apêndice vermiforme pelo acúmulo anormal de substância mucinosa em seu lúmen. Os exames de imagem podem ser úteis, porém não raramente falham em evidenciar a etiologia em questão. Em relação à abordagem terapêutica, existem diferentes opções de conduta. A apendicectomia foi o tratamento rotineiramente utilizado em cistoadenomas simples, com bons resultados. Todavia, em casos de neoplasias, é necessária ressecção mais agressiva, sendo a conduta terapêutica a hemicolectomia direita. Relato de caso: Paciente compareceu ao ambulatório de cirurgia com ressonância magnética apresentando cisto anexial de cerca de 11,0 × 4,5 cm à direita. Apresentava quadro de dor em fossa ilíaca direita há 6 meses. Devido ao achado radiológico e persistência do quadro clínico foi realizado videolaparoscopia, sendo identificada massa apendicular sugestiva de mucocele. Foi realizada apendicectomia videolaparoscópica, sem extravasamento do conteúdo mucinoso. A análise histopatológica confirmou o diagnóstico. Discussão: A mucocele raramente é diagnosticada de maneira eficaz no pré-operatório. Neste contexto, os exames de imagem não raramente falham em evidenciar tal etiologia. Diante da importância do diagnóstico pré-operatório para a definição da conduta, é essencial que sempre se leve em conta tal afecção como uma hipótese diagnóstica. Keywords: Mucocele, Laparoscopy, Diagnosis, differential, Palavras-chave: Mucocele, Laparoscopia, Diagnóstico diferencial
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- 2019
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21. Appendiceal neuroendocrine tumors: approach and treatment
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Abreu, Rui Pedro Neto da Silva
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- 2018
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22. Diagnosis and treatment of constipation: a clinical update based on the Rome IV criteria
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Sobrado, Carlos Walter, Neto, Isaac José Felippe Corrêa, Pinto, Rodrigo Ambar, Sobrado, Lucas Faraco, Nahas, Sergio Carlos, and Cecconello, Ivan
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- 2018
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23. Correlation of clinical data and the Alvarado's Score as predictors of acute appendicitis
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Cunha, Carlos Magno Queiroz da, Neto, Giovanni Troiani, Brasil, Andre Cavalcante, Menezes, Francisco Julimar Correia de, Brilhante, Aline Veras Morais, and Reinaldo, Rommel Reno Porcino
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- 2018
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24. Appendiceal neuroendocrine tumors: approach and treatment
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Rui Pedro Neto da Silva Abreu
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
The incidence of tumors in the appendix has increased over the years, and they are mainly found in the anatomical and pathological examination of appendices operated due to acute appendicitis. The annual incidence of neuroendocrine tumors of the appendix, also called carcinoid tumors, is 0.15–0.16 per 100,000 people. In absolute terms, the incidence of these tumors has increased in the last decade by 70–133%. Appendiceal carcinoid tumors occur more often in women, and are found in 0.3–0.9% of the appendices removed in appendectomies. They appear in the subepithelial neuroendocrine cells and have an indolent course, with the symptoms being indistinguishable from an acute appendicitis. There are two classifications, one presented by the European Neuroendocrine Tumor Society and the other by the American Joint Committee on Cancer. Both classifications use tumor size as a predictor of tumor burden. The classification used by European Neuroendocrine Tumor Society also uses the invasion of the mesoappendix to select the best surgical treatment. However, these classifications require the inclusion of more criteria to define the selection of surgical treatment of tumors between 1 and 2 cm. Thus, along with the size of the tumor and the invasion of the mesoappendix, other factors such as vascular invasion, ki67 index, mitotic index and tumor location should be considered at the time of classification, for a better selection of the treatment and prognostic evaluation. Resumo: A incidência de tumores no apêndice tem aumentado ao longo dos anos, principalmente encontrados no exame anatomopatológico dos apêndices operados por apendicite aguda. A incidência anual de tumores neuroendócrinos do apêndice, também designados por tumores carcinoides é de 0,15 a 0,16 por 100.000 pessoas. Em termos absolutos, a incidência destes tumores tem aumentado na última década em 70% a 133%. Os tumores carcinoides do apêndice ocorrem mais em mulheres e são encontrados em 0,3%‒0,9% dos apêndices removidos em apendicectomias. Têm origem nas células neuroendócrinas subepiteliais e apresentam um curso indolente, sendo os sintomas indistinguíveis de uma apendicite aguda. Existem duas classificações, a apresentada pela ENETS (European Neuroendocrin Tumor Society) e da AJCC (American Joint Committee on Cancer). Ambas as classificações utilizam o tamanho do tumor como preditor de carga tumoral. A classificação utilizada pela ENETS recorre ainda à invasão do mesoapêndice para selecionar o melhor tratamento cirúrgico. Contudo, estas classificações necessitam incluir mais critérios para definir a escolha do tratamento cirúrgico de tumores entre 1‒2 cm. Assim, para além do tamanho do tumor e da invasão do mesoapêndice, outros fatores como a invasão vascular, o ki67, o índice mitótico e a localização do tumor devem ser considerados no momento da classificação, para uma melhor seleção do tratamento e avaliação prognóstica. Keywords: Appendix, Neuroendocrine tumors, Carcinoids, Appendectomy, Right hemicolectomy, Palavras-chave: Apêndice, Tumores neuroendócrinos, Carcinoides, Apendicectomia, Hemicolectomia direita
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- 2018
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25. Diagnosis and treatment of constipation: a clinical update based on the Rome IV criteria
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Carlos Walter Sobrado, Isaac José Felippe Corrêa Neto, Rodrigo Ambar Pinto, Lucas Faraco Sobrado, Sergio Carlos Nahas, and Ivan Cecconello
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
The aim of this study was to evaluate the published professional association guidelines regarding the current diagnosis and treatment of functional intestinal constipation in adults and to compare those guidelines with the authors’ experience to standardize actions that aid clinical reasoning and decision-making for medical professionals. A literature search was conducted in the Medline/PubMed, Scielo, EMBASE and Cochrane online databases using the following terms: chronic constipation, diagnosis, management of chronic constipation, Roma IV and surgical treatment. Conclusively, chronic intestinal constipation is a common condition in adults and occurs most frequently in the elderly and in women. Establishing a precise diagnosis of the physiopathology of functional chronic constipation is complex and requires many functional tests in refractory cases. An understanding of intestinal motility and the defecatory process is critical for the appropriate management of chronic functional intestinal constipation, with surgery reserved for cases in which pharmacologic intervention has failed. The information contained in this review article is subject to the critical evaluation of the medical specialist responsible for determining the action plan to be followed within the context of the conditions and clinical status of each individual patient. Resumo: O objetivo deste trabalho foi avaliar os consensos de sociedade de especialistas e guidelines publicados sobre o diagnóstico e tratamento da constipação intestinal crônica em adultos, e confrontar com a experiência dos autores, a fim de padronizar condutas que auxiliem o raciocínio e a tomada de conduta do médico. Foi realizada busca na literatura científica, mais precisamente nas bases de dados eletrônicos Medline/Pubmed, Scielo, EMBASE and Cochrane, tendo sido utilizado os seguintes descritores: chronic constipation, diagnosis, management of chronic constipation, Roma IV and surgical treatment. Pode-se concluir que constipação crônica é condição comum em adultos, ocorrendo com maior frequência em idosos e mulheres. Identificar com precisão a fisiopatologia presente na constipação crônica funcional é complexo, requerendo a realização de testes funcionais nos casos refratários. O entendimento da motilidade intestinal e do mecanismo defecatório é importante para o manejo da constipação intestinal crônica funcional, sendo o tratamento cirúrgico indicado para casos selecionados, onde à abordagem medicamentosa não surtiu efeito. As informações contidas neste artigo de revisão devem ser submetidas à avaliação e à crítica do médico especialista responsável pela conduta a ser tomada, frente à sua realidade e ao estado clínico de cada paciente. Keywords: Chronic constipation, Outlet obstruction, Colonic inertia, Laxatives, Surgical treatment, Palavras-chave: Constipação crônica, Disfunção do assoalho pélvico, Inércia cólica, Laxativos, Tratamento cirúrgico
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- 2018
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26. Correlation of clinical data and the Alvarado's Score as predictors of acute appendicitis
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Carlos Magno Queiroz da Cunha, Giovanni Troiani Neto, Andre Cavalcante Brasil, Francisco Julimar Correia de Menezes, Aline Veras Morais Brilhante, and Rommel Reno Porcino Reinaldo
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Objective: To correlate the patient's clinical data and the Alvarado's Score as predictors of acute appendicitis. Methods: This is an observational, descriptive and prospective study performed at a public urgency and emergency hospital in the city of Fortaleza, Ceará, between July and December 2016, with 34 patients undergoing open appendectomy with ages between 18 and 70 years. Statistical analysis was performed using the SPSS program. Results: The following statistical correlations were performed: number of days with abdominal pain until the operative event and degree of inflammation according to a macroscopic analysis of the appendix, Alvarado's Score and number of days with abdominal pain until the operative event, Alvarado's Score and degree of inflammation according to a macroscopic analysis of the appendix, number of days with abdominal pain until the operative event, and number of days of hospitalization in the postoperative period, degree of inflammation according to amacroscopic analysis of the appendix, number of days of hospitalization in the postoperative period and Alvarado's Score, and number of days of hospitalization in the postoperative period; the first five correlations were statistically significant (p
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- 2018
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27. Retrospective analysis of patients submitted to surgical treatment of perianal fistula in Santa Marcelina Hospital, São Paulo
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Neto, Isaac José Felippe Corrêa, Wercka, Janaína, Rangel, Diego Palmeira, Lopes, Eduardo Augusto, Watté, Hugo Henriques, Souza, Rogério Freitas Lino, Rolim, Alexander Sá, and Robles, Laercio
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- 2017
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28. Laparoscopic treatment of acquired megacolon
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LH, Oliveira, SO, Banci, O, Kagohara, J, Simões Neto, JA, Reis Junior, and JA, Reis Neto
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- 2014
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29. Results of videolaparoscopic surgical treatment of diverticular disease of the colon
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Rodrigues, Vinícius Pires, Queiroz, Fábio Lopes de, Neto, Paulo Rocha França, and Carvalho e Carvalho, Maria Emília
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- 2017
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30. Neoadjuvant radiotherapy in stage I cancer of the lower rectum
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José Alfredo dos Reis Neto, José Alfredo dos Reis Junior, Odorino Hideyoshi Kagohara, Joaquim Simões Neto, Sergio Oliva Banci, Luciane Hiane Oliveira, Gustavo Alejandro Gutierrez Espinoza, and Antonio José Tiburcio Alves Júnior
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: The mortality rate in low rectal cancer is related to pelvic and distant recurrence. For stage I tumors, local excision has being used increasingly, but recent studies show the need for caution with the use of this technique, as they do not consider the possibility of a positive node in stage I rectal tumors. Therefore, preoperative radiotherapy should be considered for early tumors, as an attempt to prevent recurrence. Objective: Show the effectiveness of neoadjuvant radiotherapy in stage I cancer of the lower rectum of a cohort population. Material and method: A cohort study in a prospective database was made with a total of 538 patients, of which were considered 75 patients with stage I lower rectal cancer. Preoperative radiotherapy was performed and patients were followed up for a minimum period of five years. Results: Stage I/TI group had 27 patients. All of them presented complete response to the treatment and did not need to be operated. During the follow up time of five years, this group showed no recurrence rate. The stage I/TII group had 48 patients. During the follow up, 8 patients had to be operated due to suspicious lesion or scar. They were submitted to full total local excision. After evaluating the pathological specimen, none of them proved to be adenocarcinoma. Conclusion: Preoperative radiation, not only reduced the local recurrence and mortality rate in lower rectal cancer, but also reduced the need for surgery in patients with stage I cancer. Resumo: Introdução: O percentual de mortalidade em pacientes com câncer de reto baixo está relacionado a recorrências pélvica e remota. No caso de tumores no estágio I, a excisão local vem sendo utilizada cada vez mais; contudo, estudos recentemente publicados demonstraram a necessidade de se ter cautela com o uso dessa técnica, por não se levar em consideração a possibilidade de um nodo positivo em tumores de reto no estágio I. Portanto, a radioterapia pré-operatória é uma opção viável para os tumores em fase inicial, como uma tentativa de evitar recorrência. Objetivo: Demonstrar a eficácia da radioterapia neoadjuvante em casos de câncer de reto baixo no estágio I em uma coorte da população. Materiais e métodos: Foi realizado um estudo de coorte em um banco de dados prospectivo, com envolvimento, no total, de 538 pacientes, dos quais 75 foram considerados como tendo câncer de reto baixo no estágio I. No pré-operatório, os pacientes foram tratados com radioterapia e seguidos durante um período mínimo de 5 anos. Resultados: O Grupo no estágio I/TI consistia em 27 pacientes. Todos obtiveram resposta completa ao tratamento e não houve necessidade de reoperação. Durante o período de 5 anos de seguimento, não houve recorrências nesse grupo. O grupo no estágio I/TII consistia em 48 pacientes. Durante o seguimento, 8 pacientes tiveram que ser operados, devido à suspeita de lesão, ou cicatriz. Para esses casos, optou-se por excisão local total completa. Após a avaliação dos espécimes patológicos, nenhum deles teve diagnóstico de adenocarcinoma. Conclusão: O uso da radiação pré-operatória não só diminuiu a recorrência local e o percentual de mortalidade em casos de câncer de reto baixo, mas também diminuiu a necessidade de cirurgia em pacientes com câncer no estágio I. Keywords: Rectal neoplasms, Radiotherapy, Mortality, Irradiation, Palavras-chave: Neoplasias retais, Radioterapia, Mortalidade, Irradiação
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- 2016
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31. Anorectal hemangioma – differential diagnosis of anal bleeding
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Walter Batista de Santana Neto, Giovanni Troiani Neto, Carlos Magno Queiroz da Cunha, André Cavalcante Brasil, and José Ney Primo Feitosa
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Anorectal hemangioma is one of the rarest causes of lower gastrointestinal bleeding, but is often neglected and confused in the differential diagnosis. The clinical examination is a turning point for a correct diagnosis and management of patients, thus avoiding unnecessary procedures. The treatment of choice for this condition is surgical and intraoperative bleeding is the main complication of this therapy. The present case reports a 25-year old patient with a history of bleeding from the age of 13, being diagnosed with anorectal hemangioma, and surgically treated with resection of the affected segment and with wound synthesis by marsupialization, with a good progression postoperatively. Resumo: O Hemangioma Anorretal é uma das mais raras causas de Hemorragia digestiva baixa, sendo muitas vezes negligenciada e confundida no diagnóstico diferencial. O exame clínico representa um ponto decisivo para correto diagnóstico e manejo do paciente, evitando realização de exames desnecessários, e o tratamento de escolha dessa patologia é cirúrgico, sendo o sangramento intraoperatorio a principal complicação dessa terapêutica. O relato de caso a seguir reporta a história de paciente com 25 anos, que apresentava sangramento desde os 13, sendo diagnosticado com Hemangioma Anorretal e tratado cirurgicamente com ressecção do segmento afetado e síntese de ferida com marsupialização, evoluindo bem no pós-operatório. Keywords: Hemangioma, Anorectal, Diagnosis, Surgery, Palavras-chave: Hemangioma, Anorretal, Diagnóstico, Cirurgia
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- 2017
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32. Retrospective analysis of patients submitted to surgical treatment of perianal fistula in Santa Marcelina Hospital, São Paulo
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Isaac José Felippe Corrêa Neto, Janaína Wercka, Diego Palmeira Rangel, Eduardo Augusto Lopes, Hugo Henriques Watté, Rogério Freitas Lino Souza, Alexander Sá Rolim, and Laercio Robles
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Perianal fistula is a condition commonly found in surgical practice, with an incidence of approximately 1 in 10,000 individuals, with a predisposition for the male gender, occurring mainly in patients between 30 and 50 years and in 80% of the cases originating from infection in the glandular crypts (cryptoglandular). Objective: To perform a retrospective analysis using electronic medical record data of patients submitted to surgical treatment for perianal fistula in Santa Marcelina Hospital in São Paulo, as well as to verify the incidence of relapse and anal continence disorders, in addition to the complexity and types of fistulas and patient characterization. Results: Two hundred patients were submitted to surgical treatment of perianal fistula were analyzed. Among men, there was a higher incidence of patients with lower educational level (p = 0.02), hypertension (0.03), diabetes (0.05), older age (p = 0.001), whereas among women previous perianal abscess predominated (0.001). There was no statistical difference in anal continence between patients submitted to fistulotomy with or without seton. Conclusion: We observed a predominance of male patients and a low incidence of recurrence and symptoms of anal continence disorders, in addition to a predominance of complex fistulas. Resumo: Introdução: Fístula perianal é uma condição comumente encontrada na prática cirúrgica com incidência de cerca 1 em 10000 indivíduos com predisposição para o sexo masculino, ocorrendo fundamentalmente em pacientes entre 30 e 50 anos e em 80% dos casos tem origem em infecção nas criptas glandulares (criptoglandular). Objetivo: Realizar análise retrospectiva através de dados de prontuário eletrônico de pacientes submetidos a tratamento cirúrgico de fístula perianal no Hospital Santa Marcelina São Paulo, além de verificar a incidência de recidiva e desordens da continência anal, além da complexidade e tipos das fístulas e caracterização dos pacientes. Resultados: Duzentos pacientes foram submetidos a tratamento cirúrgico de fístula perianal. Entre os homens houve maior incidência de pacientes com menor escolaridade (p = 0,02), hipertensos (0,03), diabéticos (0,05), maior idade (p = 0,001) e nas mulheres predominou abscesso perianal prévio (p = 0,001). Não houve diferença estatística na continência anal entre os pacientes submetidos a fistulotomia com ou sem sedenho. Conclusão: Verifica-se predomínio de pacientes do sexo masculino e uma baixa incidência de recidiva e sintomas de desordens da continência anal, além de um predomínio de fístulas complexas. Keywords: Perianal fistula, Demographic data, Relapse, Anal incontinence, Palavras-chave: Fístula perianal, Dados demográficos, Recidiva, Incontinência anal
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- 2017
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33. Hemipelvectomy with laparoscopic abdominoperineal excision for epithelioid sarcoma treatment
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Daniel Paulino Santana, Matheus Matta Machado Mafra Duque Estrada Meyer, Edmilson Celso Santos, Camila Gomes de Souza Andrade, Paulo Vilela Neto, Aline Alves Matoso, Bruna Sílvia Torres Santos, Bruno José Guedes Silva, Danielle Bossi Grassi Ferreira, Larissa Vasconcelos Horta, and Marcos Campos Wanderley Reis
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
The epithelioid sarcoma (ES) is an unusual variant of the sarcoma, not reaching 1% of all soft tissue sarcomas. Initially reported in 1970, it has a more aggressive variant, which was classified as the “proximal-type” in 1997. These are aggressive tumors with high rates of distant metastasis and local relapses. Isolated radio and chemotherapy responses are poor and free-margin surgical resection is the treatment of choice.This is the case report of a 25-year-old male patient diagnosed with “proximal-type” ES in the perineal region. He underwent surgical resection in another institution and was later admitted to our institution with local recurrence with rectal and left thigh muscle invasion. Neoadjuvant radio-chemotherapy was performed, followed by laparoscopic abdominoperineal rectal resection and partial left hemipelvectomy associated with left lower-limb amputation. The patient had no postoperative complications and is currently undergoing outpatient follow-up. The anatomopathological analysis showed tumor-free margins.The “proximal-type” ES is a rare soft-tissue sarcoma subtype. High local recurrence, as well as the metastasis rates, makes its treatment a challenging task. Resumo: O sarcoma epitelióide (SE) é um subtipo incomum de sarcoma, não chegando a 1% dos sarcomas de partes moles. Foi inicialmente descrito em 1970, sendo que em 1997 uma variante mais agressiva foi classificada como “tipo proximal”. São tumores agressivos, com altas taxas de metástases e recidiva local, com resposta pobre à quimioterapia e radioterapia isoladas. A ressecção cirúrgica com margens livres é o tratamento padrão.Apresentamos o caso de um paciente de 25 anos com SE tipo proximal avançado em região perineal, submetido a ressecção em outro serviço, evoluindo com recidiva local com invasão do canal anal e musculatura da coxa esquerda. Foi realizado tratamento radioquimioterápico neoadjuvante seguido de ressecção cirúrgica com amputação abdominoperineal do reto por videolaparoscopia associada a hemipelvectomia parcial esquerda incluindo o membro inferior esquerdo (MIE). O paciente apresentou boa evolução pós operatória e encontra-se em segmento ambulatorial. O anatomopatológico evidenciou margens cirúrgicas livres.O SE proximal é um tipo raro de sarcoma de partes moles, cujo tratamento curativo é desafiador, em virtude dos altos índices de recidiva local e metástases à distância. Keywords: Sarcoma, Epithelioid sarcoma, Soft tissue sarcoma, Neoplasm, Palavras chave: Sarcoma, Sarcoma epitelióide, Sarcoma de tecidos moles, Neoplasia
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- 2017
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34. Giant appendiceal mucinous cystadenoma treated by laparoscopy: a case report and review of the literature
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Felipe Ramos Nogueira, Francisco Wendel de Sousa Arruda, Carla Camila Rocha Bezerra, Benjamin Ramos de Andrade Neto, Manoel Italo Pimentel Santos Lopes, Edson de Macedo Sousa, Alessandra Marques dos Santos, Adryano Gonçalves Marques, and Lusmar Veras Rodrigues
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Appendiceal mucinous cystadenoma is a rare entity, which causes appendicular mucocele. It is more frequent in women over 50 years old. In half of the cases it is asymptomatic. Tomography of the abdomen is the gold standard in its preoperative diagnosis. The treatment is surgical, with good prognosis, the complete resection evolves without appendicular rupture and extravasation. We report a case of a 64-year-old man with appendiceal mucinous cystadenoma. A laparoscopic right hemicolectomy was performed. This therapy that can be safely used to treat appendiceal mucocele, as long as it is cautious. Resumo: O cistadenoma mucinoso apendicular é entidade rara que causa mucocele apendicular, sendo mais frequente em mulheres acima dos 50 anos. Em metade dos casos, o cistadenoma mucinoso apendicular é assintomático. A tomografia do abdome é o padrão-ouro para um diagnóstico pré-operatório. O tratamento é cirúrgico e tem bom prognóstico; a ressecção completa evolui sem ruptura apendicular e sem extravasamento. Relatamos um caso de paciente homem de 64 anos com cistadenoma mucinoso apendicular. Foi realizada hemicolectomia laparoscópica direita. Esse é um procedimento que pode ser usado com segurança no tratamento de mucocele apendicular, desde que seja executado com cautela. Keywords: Cystadenoma, mucinous, Appendiceal neoplasms, Mucocele, Pseudomyxoma peritonei, Palavras-chave: Cistadenoma mucinoso, Neoplasias apendiculares, Mucocele, Pseudomixoma peritoneal
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- 2017
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35. Results of videolaparoscopic surgical treatment of diverticular disease of the colon
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Vinícius Pires Rodrigues, Fábio Lopes de Queiroz, Paulo Rocha França Neto, and Maria Emília Carvalho e Carvalho
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Diverticular disease of the colon (DDC) is the fifth most common gastrointestinal disease in developed Western countries, with mortality rates of 2.5 per 100,000 inhabitants per year. Objective: The objective of this study is to compare the occurrence of complications, conversion rate, use of stoma, deaths and time of hospitalization among patients undergoing rectosigmoidectomy for DDC and patients undergoing the same surgery for other reasons. Method: This was an observational retrospective comparative study. This study was approved by the ethics committee of the Hospital Felicio Rocho – Minas Gerais, Brazil – and the data were obtained from the same hospital database. Results: The groups were classified according to age, gender, presence of comorbidities, and ASA classification. There was no evidence indicating a significant difference between groups. In this analysis, no perioperative complications were observed and there was no need for a stoma, and no deaths or fistulas occurred. Conclusion: Elective laparoscopic surgical treatment of DDC in the analyzed group showed no difference in complications, duration of surgery and hospitalization time versus control group. Therefore, the laparoscopic surgical treatment of diverticular disease translates into an excellent tool for both the surgeon and the patient. Resumo: Introdução: A Doença Diverticular do Cólon (DDC) é a quinta doença gastrointestinal mais frequente nos países desenvolvidos do ocidente com índices de mortalidade de 2,5 por 100.000 habitantes por ano. Objetivo: O objetivo desse estudo é comparar a ocorrência de complicações, taxa de conversão, utilização de estoma, óbito e tempo de internação entre pacientes submetidos a retossigmoidectomia por DDC e pacientes submetidos ao mesmo procedimento cirúrgico por outras causas. Método: Trata-se de um estudo comparativo, retrospectivo observacional. Este estudo foi aprovado pelo comitê de ética do Hospital Felício Rocho - Minas Gerais, Brasil - e os dados foram obtidos no banco de dados do mesmo hospital. Resultados: Os grupos foram classificados em relação à idade, sexo, presença ou não de comorbidades e classificação ASA. Observou-se que não existem evidências indicando diferença significativa entre os grupos. Não houveram complicações per-operatórias, necessidade de estoma, bem como óbitos ou fístulas nesta análise. Conclusão: O tratamento cirúrgico eletivo videolaparoscópico da DDC no grupo analisado não apresentou diferença quanto às complicações, o tempo de cirurgia e o tempo de internação em relação ao grupo controle. Portanto, o tratamento cirúrgico laparoscópico da doença diverticular traduz-se em excelente ferramenta tanto para o cirurgião quanto para o paciente. Keywords: Disease diverticular, Colorectal cancer, Videolaparoscopy, Palavras-chave: Doença diverticular, Câncer colorretal, Videolaparoscopia
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- 2017
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36. High macro rubber band ligature
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Neto, José A. Reis, Junior, José A. Reis, Kagohara, Odorino H., Neto, Joaquim Simões, Banci, Sergio O., and Oliveira, Luciane H.
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- 2013
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37. There is an agreement between constipation referred and that documented by objective criteria?
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Neto, Isaac José Felippe Corrêa, Maneira, Ana Luiza Chaves, Teixeira, Noelle Breda, Vettorato, Beatriz Doine, de Oliveira, Mariana Campello, Menezes, Tatielle Alves Trivelato, and Robles, Laercio
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- 2016
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38. Perianal abscess: a descriptive analysis of cases treated at the Hospital Santa Marcelina, São Paulo
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Neto, Isaac José Felippe Corrêa, Wercka, Janaína, Cecchinni, Angelo Rossi Silva, Lopes, Eduardo Augusto, Watté, Hugo Henriques, Souza, Rogério Freitas Lino, Rolim, Alexander Sá, and Robles, Laercio
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- 2016
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39. Retrospective analysis of the elective tests of rigid proctosigmoidoscopy performed in the service of medical residency in Coloproctology of Hospital Santa Marcelina
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Neto, Isaac José Felippe Corrêa, Wercka, Janaína, Cecchinni, Angelo Rossi Silva, Lopes, Eduardo Augusto, Watté, Hugo Henriques, Souza, Rogério Freitas Lino, Rolim, Alexander Sá, and Robles, Laercio
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- 2016
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40. Epidemiological characterization of ostomized patients attended in referral Center from the city of Maceió, Alagoas, Brazil
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de Freitas Lins Neto, Manoel Álvaro, de Araújo Fernandes, Danillo Omena, and Didoné, Eveline Leite
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- 2016
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41. CORREÇÃO DE RETOCELE COM MACROLIGADURA ELÁSTICA
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Bassani, Matheus de Carvalho, additional, Reis, José Alfredo dos, additional, Kagohara, Odorino Hideyoshi, additional, Neto, Joaquim Simões, additional, Banci, Sérgio Oliva, additional, Oliveira, Luciane Hiane, additional, Alves, Antonio José Tibúrcio, additional, and Neto, José Alfredo dos Reis, additional
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- 2022
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42. MACROLIGADURA ALTA NA DOENÇA HEMORROIDÁRIA INTERNA
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Bassani, Matheus de Carvalho, additional, Júnior, José Alfredo dos Reis, additional, Kagohara, Odorino Hideyoshi, additional, Neto, Joaquim Simões, additional, Banci, Sérgio Oliva, additional, Oliveira, Luciane Hiane, additional, Alves, Antonio José Tibúrcio, additional, and Neto, José Alfredo dos Reis, additional
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- 2022
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43. Retrospective Study of Patients Submitted to Appendectomy in a Tertiary Hospital: Is There a Difference between the Public and Supplementary Health System?
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Corrêa Neto, Isaac José Felippe, Robles, Amanda Gambi, Nishiyama, Victor Keniti Gomes, Arita, Sany Tomomi de Almeida Rocha, Sperandio, Gabriel Fiorot Cruz, Nishikawa, Lia Yumi Omori, Pinto, Rodrigo Ambar, and Robles, Laercio
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- 2024
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44. DOENÇA DE BOWEN PERIANAL: RELATO DE CASO
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Antonio Custodio da Costa Júnior, Felipe Soares Branquinho, Calil Salomão Abud Neto, Vimael Jefferson de Oliveira Holanda, Edvaldo Silva Lima, Ernandi Araujo Lima Neto, and Murilo Boavista Pessoa Mendes
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2017
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45. LEIOMIOMA COLORRETAL: TRATAMENTO ENDOSCÓPICO – RELATO DE CASO
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Felipe Soares Branquinho, Antonio Custodio da Costa Junior, Calil Salomao Abud Neto, Murilo Boa Vista Pessoa Mendes, Edvaldo Silva Lima, Vimael Jefferson de Oliveira Holanda, and Ernandi Araujo Lima Neto
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2017
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46. Incidence of Intestinal Constipation During the COVID-19 Pandemic Period in Medical Students from a Private Institution in São Paulo, SP
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Neto, Isaac José Felippe Corrêa, additional, Silva, Alisson de Lucena, additional, Tajiri, Renato Cardoso de Melo, additional, Theis, Cláudia, additional, Schelle, Gabriela, additional, Pinto, Rodrigo Ambar, additional, Nishiyama, Victor Keniti Gomes, additional, and Robles, Laercio, additional
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- 2023
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47. Perianal abscess: a descriptive analysis of cases treated at the Hospital Santa Marcelina, São Paulo
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Isaac José Felippe Corrêa Neto, Janaína Wercka, Angelo Rossi Silva Cecchinni, Eduardo Augusto Lopes, Hugo Henriques Watté, Rogério Freitas Lino Souza, Alexander Sá Rolim, and Laercio Robles
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Perianal suppurations have an incidence of 1–2:10,000 inhabitants per year and represent about 5% of proctology consultations, more frequently in males, being rare in childhood. Although perianal or anorectal abscess is an entity of relatively simple diagnosis and treatment, in a considerable percentage of patients difficulties will be found, especially considering that the initial treatment of these patients is performed by non-specialist physicians. Objective: This is a retrospective survey of cases of perianal and anorectal abscess operated in Santa Marcelina Hospital between October 2011 and December 2014. Patients and methods: A retrospective study of patients operated on an emergency basis for perianal and/or anorectal abscess in Santa Marcelina Hospital between October 2011 and December 2014, being excluded patients with inflammatory bowel disease. Data of gender, age, clinical presentation, the season of the year in which the abscess occurred, time of progression of symptoms, comorbidities, signs of Systemic Inflammatory Response Syndrome (SIRS) on admission, surgeries carried out, reoperations and clinical outcome were analyzed. Results: Electronic medical records of 52 patients (73.1% male) who underwent surgical treatment of anorectal and perianal abscess were analyzed. The mean overall age was 43.03 years, and all patients reported pain as the main symptom, with a mean time of symptoms of 6.5 days. As for the season of the year of onset and diagnosis of perianal abscess, 61.5% of patients had this pathology in the summer and spring months. Conclusion: In our study, it can be observed a higher incidence of perianal abscess in males and in the warmer months; furthermore, just over half of the patients developed perianal fistula in their progression. Resumo: Introdução: As supurações perianais apresentam uma incidência de 1-2:10000 habitantes por ano e representam cerca de 5% das consultas proctológicas, com maior frequência no sexo masculino, sendo raras na infância. Embora o abscesso perianal ou anorretal seja de diagnóstico e tratamento relativamente simples, uma percentagem considerável representa maior dificuldade para tal, notadamente pelo fato do atendimento inicial desses pacientes ser realizado por médicos não especialistas. Objetivo: Levantamento retrospectivo dos casos de abscesso perianal e anorretal operados no Hospital Santa Marcelina entre outubro de 2011 e dezembro de 2014. Casuística e método: Estudo retrospectivo de pacientes operados em caráter de urgência por abscesso perianal e/ou anorretal no Hospital Santa Marcelina entre outubro de 2011 e dezembro de 2014, excluídos portadores de doença inflamatória intestinal. Analisaram-se dados de sexo, idade, quadro clínico, época do ano da ocorrência do abscesso, tempo de evolução dos sintomas, comorbidades, sinais de Síndrome da Resposta Inflamatória Sistêmica (SIRS) na admissão, cirurgias realizadas, reoperações e desfecho clínico. Resultados: Foram analisados prontuários eletrônicos de 52 pacientes submetidos à tratamento cirúrgico de abscesso anorretal e perianal, dos quais 73,1% pertenciam ao sexo masculino. A média de idade geral foi de 43,03 anos e todos os pacientes relataram dor como sintoma principal com média de tempo de sintomatologia de 6,5 dias. Quanto à época do ano do aparecimento e diagnóstico do abscesso perianal, 61,5% dos pacientes apresentaram a patologia nos meses de verão e primavera. Conclusão: Em nosso trabalho, pode-se observar maior incidência de abscesso perianal no sexo masculino e nos meses mais quentes e que pouco mais da metade dos pacientes desenvolveram fístula perianal na evolução. Keywords: Perianal abscess, Medical history, Signs of syndrome of systemic inflammatory response, Surgery, Seasonality, Palavras-chave: Abscesso perianal, História clínica, Sinais de síndrome da resposta inflamatória sistêmica, Cirurgia, Sazonalidade
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- 2016
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48. There is an agreement between constipation referred and that documented by objective criteria?
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Isaac José Felippe Corrêa Neto, Ana Luiza Chaves Maneira, Noelle Breda Teixeira, Beatriz Doine Vettorato, Mariana Campello de Oliveira, Tatielle Alves Trivelato Menezes, and Laercio Robles
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Chronic constipation is the most common digestive complaint at the doctor's office, with high prevalence in the population. However, many patients – and even those physicians not so familiar with pelvic floor disorders–define and consider constipation based on intestinal functionality and stool consistency. But symptoms of incomplete defecation, digital maneuvers, abdominal discomfort, and straining should not be overlooked. Objectives: To investigate the correlation between constipation referred and documented through objective criteria in patients admitted on a daytime-nursing ward basis at the Hospital Santa Marcelina, São Paulo. Methodology: This is a prospective study of a random sample of patients admitted on a daytime-ward hospitalization basis at Santa Marcelina Hospital to perform minor surgical procedures not related to functional disorders of the gastrointestinal tract in the period from September 2014 to June 2015; the only exclusion criterion was “not agreed to participate in the interview conducted by students of medicine at Santa Marcelina Medical School”. Results: 102 patients were randomly analyzed in the period considered (51% female) with a mean overall age of 48.6 (19–82) years. Constipation has been reported spontaneously by 17.6% of participants and denied by 82.4%. With the implementation of the Cleveland Clinic's criteria for the diagnosis of constipation, the compliance with the referred symptomatology was 88.9%; the same value was found with the use of the Rome III criteria (Kappa = 0.665). In addition, a higher incidence of constipation was observed in female patients (p = 0.002). Conclusion: A higher incidence of constipation was observed in female participants, with no statistical difference with respect to age. Furthermore, a substantial agreement was found between constipation referred and constipation documented through objective criteria. Resumo: Introdução: A constipação intestinal crônica representa a queixa digestiva mais comum no consultório com elevada prevalência na população. No entanto, frequentemente, os pacientes e mesmo os médicos, não tão afeitos com os distúrbios do assoalho pélvico, definem e consideram constipação baseados na funcionalidade intestinal e consistência das fezes. Entretanto, os sintomas de defecação incompleta, manobras digitais, desconforto abdominal e esforço evacuatório não devem ser negligenciados. Objetivos: Verificar a correlação entre constipação intestinal referida e constatada através de critérios objetivos em pacientes internados em regime de enfermaria dia no Hospital Santa Marcelina, São Paulo. Metodologia: Estudo prospectivo de amostra aleatória de pacientes internados em enfermaria dia do Hospital Santa Marcelina para realização de cirurgias de pequeno porte e não relacionadas a distúrbios funcionais de trato gastrintestinal no período entre setembro de 2014 e junho de 2015, cujo único critério de exclusão foi o não consentimento em participar da entrevista realizada pelos alunos do curso de medicina da Faculdade Santa Marcelina. Resultados: Foram analisados de forma aleatória 102 pacientes no período sendo 51% do sexo feminino e média de idade global de 48,6 anos (19-82 anos). A constipação foi referida de forma espontânea em 17,6% e negada em 82,4%. Ao se utilizar o critério da Cleveland Clinic para constatar constipação houve uma concordância com o sintoma referido fora de 88,9%, com mesmo valor ao se utilizar os critérios de Roma III (Kappa = 0,665). Além disso, verificou-se maior incidência de constipação intestinal nos pacientes do sexo feminino (p = 0,002). Conclusão: Verificou-se maior incidência de constipação no sexo feminino sem diferença estatística baseado na idade. Além disso, constatou-se concordância substancial entre a constipação referida e a documentada através de critérios objetivos. Keywords: Constipation, Rome criteria, Kappa index, Palavras-chave: Constipação intestinal, Critérios de Roma, Índice de Kappa
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- 2016
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49. Laparoscopic treatment of acquired megacolon
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Oliveira LH, Banci SO, Kagohara O, Simões Neto J, Reis Junior JA, and Reis Neto JA
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
In spite of the large experience acquired in the last 50 years with the surgical treatment of the Chagasic megacolon, the use of colorectal video laparoscopic surgery brought some controversy in several aspects of the treatment that already had been considered as re- solved. One of the basic aspects to the establishment of the colorectal video laparoscopic surgery is to maintain the same procedure of the conventional surgery, since the results obtained in this operation were considered as curative. Constipation is only a symptom of a multisymptomatic disease, and the surgical treatment of acquired megacolon must be considered as definitive in the cure of this symptom; recurrence of the constipation or dilatation after a short period of time must be considered deleterious to the patient. Based in 41 years of experience with the Duhamel procedure in the treatment of 912 patients with acquired megacolon, the authors propose to apply the same technique in the surgical laparoscopic approach of acquired megacolon, including the same colon-recto-anal anas- tomosis. The results obtained in 56 patients operated on by laparoscopic approach showed the same curative results, but with lower morbidity. Resumo: Apesar da vasta experiência adquirida nos últimos 50 anos com o tratamento cirúrgico do megacolo adquirido, a introdução da cirurgia laparoscópica voltou a trazer controvérsia para alguns pontos anteriormente considerados como esclarecidos. Uma das regras básicas para a introdução da videolaparoscopia no tratamento das enfermidades colorretais tem sido a de se manter a técnica original utilizada em cirurgias pela via convencional, desde que os resultados observados na mesma conduzam à cura dos sintomas ou da enfermidade causal. Em especial, no referente ao tratamento cirúrgico do megacolo adquirido a proposta de um tratamento cirúrgico deve ter em mente que diferentemente do que ocorre com a cirurgia para tratamento de outras enfermidades, benignas ou malignas, neste caso não se almeja o tratamento causal da enfermidade, mas essencialmente a cura da manifestação de um de seus sintomas. É, pois, realmente importante que se considere um tratamento que não venha a resultar em bons resultados por apenas um curto espaço de tempo, mas que possibilite ao paciente livrar-se definitivamente de um sintoma, visto que é possível que em curto espaço de tempo ele venha a necessitar tratar outra manifestação sintoma- tológica (cardíaca ou esofágica) da enfermidade causal. Baseados na experiência adquirida nos últimos 50 anos (912 pacientes) com a técnica de Duhamel, em que o ponto importante é a realização de uma ampla anastomose da parede anterior do cólon abaixado à parede posterior (mucosa) do reto, ao mesmo tempo em que se anastomosa a parede posterior do cólon abaixado ao canal anal, são analisados os resultados obtidos com esta mesma técnica realizada por laparoscopia. Esta mesma incisão no canal anal serve para a retirada do seg- mento cólico ressecado, sem necessidade de laparotomia auxiliar. Os resultados observa- dos em 56 pacientes quanto à cura da obstipação são similares aos registrados na cirurgia convencional, porém com um menor índice de morbidade, seja intra ou pós-operatória. Keywords: Obstipation Constipation Acquired megacolon Laparoscopy Duhamel surgery Mechanic colon-recto-anal anastomosis, Palavras-chave: Obstipação Constipação Megacolo adquirido Laparoscopia Cirurgia de Duhamel Anastomose cólon-reto-anal mecânica
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- 2014
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50. Retrospective analysis of the elective tests of rigid proctosigmoidoscopy performed in the service of medical residency in Coloproctology of Hospital Santa Marcelina
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Isaac José Felippe Corrêa Neto, Janaína Wercka, Angelo Rossi Silva Cecchinni, Eduardo Augusto Lopes, Hugo Henriques Watté, Rogério Freitas Lino Souza, Alexander Sá Rolim, and Laercio Robles
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Introduction: Proctologic examination is a deeply intimate procedure which deals with a body area in which prejudices, taboos and constraints prevail, and may also relate to previous trauma; yet this procedure is of paramount importance for the investigation of patients with symptoms that foretell pathologies associated with distal colon, rectum and anus. Objectives: This study aimed to analyze all cases scheduled of rigid proctosigmoidoscopy performed by the Coloproctology Service, Hospital Santa Marcelina, in 8 of its 10 years of residency in the specialty. Materials and methods: We analyzed mean age, gender distribution, device's height of reach in relation to the anal verge, the percentage of abnormal tests stratified to perform, or not perform, anoscopy and proctosigmoidoscopy, and major diseases detected. Results: 844 rigid proctosigmoidoscopy procedures scheduled and performed by the Coloproctology Service, Hospital Santa Marcelina, between September 2006 and August 2014, were analyzed. The distribution was similar between genders and the mean age was 51.2 years. With respect to the device's height of reach from the anal verge, these values were stratified as follows: distance reached >15 cm, 10–15 cm, and 15 cm from the anal verge were attained in 692 (82% of RR) tests, between 10 and 15 cm in 94 (11.1%) tests, and
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- 2016
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