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Mosquito control is facing a challenge worldwide, due to ineffectiveness of chemical insecticides. Identification of novel and ecofriendly insecticides is the need of the hour. In the present study mosquito control efficacy, antioxidants and anti-cancerous potential of silver nanoparticle conjugated with Carmona retusa (Vahl) Masam nanoparticles. Synthesized nanoparticles had UV absorption maximum at 420 nm, size ranging between 20 and 40 nm based of TEM, has cubic structure, C-H bending and Ag Metal bands. Results show high free radical scavenging ability of C. retusa derived silver nanoparticles as evidenced by DPPH radical and H2O2 radical assay. C. retusa derived nanoparticles produce 80% inhibition in MCF-7 cell line at concentration of 500 μg/ml. High larvicidal activity with LC50 values of 116.681 ppm for Anopheles stephensi, 198.766 ppm for Aedes aegypti, and 83.553 ppm for Culex quinquefasciatus were observed. Based on the findings of the study we suggest that C. retusa plant mediated AgNPs has anticancerous and mosquito larvicidal property and could be bioprospected for drug development and mosquito control. [ABSTRACT FROM AUTHOR]