1. Elevated chemokine levels during adult but not pediatric Crimean-Congo hemorrhagic fever
- Author
-
Furuzan Kokturk, Mustafa Gökhan Gözel, Gulay Korukluoglu, Mehmet Ceyhan, Alexander J. McAuley, Ali Kaya, Yasemin Ozsurekci, Nazif Elaldi, Mehmet Arasli, Dilek Yagci Caglayik, Mehmet Bakir, Ishak Ozel Tekin, Eda Karadag Oncel, Dennis A. Bente, Fusun Dilara Icagasioglu, Zonguldak Bülent Ecevit Üniversitesi, [Arasli, Mehmet -- Tekin, Ishak Ozel] Bulent Ecevit Univ, Sch Med, Dept Immunol, Zonguldak, Turkey -- [Ozsurekci, Yasemin -- Oncel, Eda Karadag -- Ceyhan, Mehmet] Hacettepe Univ, Sch Med, Dept Paediat Infect Dis, Ankara, Turkey -- [Elaldi, Nazif -- Gozel, Mustafa Gokhan -- Bakir, Mehmet] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [McAuley, Alexander J. -- Bente, Dennis A.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA -- [McAuley, Alexander J. -- Bente, Dennis A.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA -- [Kaya, Ali -- Icagasioglu, Fusun Dilara] Cumhuriyet Univ, Sch Med, Dept Paediat, Sivas, Turkey -- [Caglayik, Dilek Yagci -- Korukluoglu, Gulay] Refik Saydam Natl Publ Hlth Agcy, Virol Reference & Res Lab, Ankara, Turkey -- [Kokturk, Furuzan] Bulent Ecevit Univ, Sch Med, Dept Biostat, Zonguldak, Turkey, McAuley, Alexander -- 0000-0002-7632-9633, Elaldi, Nazif -- 0000-0002-9515-770X, Gozel, Mustafa Gokhan -- 0000-0001-5187-7388, tekin, ishak ozel -- 0000-0002-9969-4254, and İÇAĞASIOĞLU, DİLARA FÜSUN
- Subjects
Crimean–Congo hemorrhagic fever ,Adult ,Male ,Chemokine ,Adolescent ,CCL3 ,CCL4 ,CCL2 ,Young Adult ,Immune system ,Virology ,Granulocyte Colony-Stimulating Factor ,Medicine ,Adults ,Humans ,Interleukin 8 ,Child ,Children ,Aged ,Immunoassay ,biology ,business.industry ,Age Factors ,Infant ,Middle Aged ,medicine.disease ,Flow Cytometry ,Infectious Diseases ,Child, Preschool ,Immunology ,biology.protein ,CXCL9 ,Crimean-Congo hemorrhagic fever ,Female ,Hemorrhagic Fever, Crimean ,Chemokines ,business - Abstract
WOS: 000352702000018, PubMed ID: 25866343, Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis. Clinical reports indicate the severity of CCHF is milder in children than adults. The chemokines are important chemoattractant mediators of the host immune system. Objectives: The main aim of the study was to identify whether or not there were any differences in chemokine levels between the pediatric and adult patients and control groups, and whether there was any correlation with disease severity. Study design: The serum levels of select chemokines including chemokine (C-C) ligand 2 (CCL2), CCL3, CCL4, chemokine (C-X-C) ligand 8 (CXCL8), CXCL9, and granulocyte-colony stimulating factor (G-CSF) in 29 adult and 32 pediatric CCHF patients and in 35 healthy children and 40 healthy adult control groups were studied by flow cytometric bead immunoassay method. Results: Great variability was detected in the serum levels of the chemokines for both the adult and pediatric patients and controls. With the exception of G-CSF, the median serum levels of CCL2, CCL3, CCL4, CXCL8, and CXCL9 were found to be significantly higher in the adult patients compared to adult controls (2364.7 vs. 761 pg/ml; 714.1 vs. 75.2 pg/ml; 88.6 vs. 25.5 pg/ml; 217.9 vs. 18.3 pg/ml; 875 vs. 352.2 pg/ml, respectively, p < 0.0001 for all comparisons). Among the chemokines the median CCL4 and G-CSF levels were significantly higher in the pediatric patients compared to pediatric controls (40.3 vs. 7.1 pg/ml, p < 0.0001; 0.1 vs. 0.1 pg/ml, p = 0.049, respectively). Conclusion: The results of this study showed prominent chemokine raising in adult CCHF patients compared to children CCHF patients. (C) 2015 Elsevier B.V. All rights reserved.
- Published
- 2014