1. The association of Torque Teno viral load with CMV and BKV infection in pediatric and adolescent kidney transplant patients.
- Author
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Eibensteiner, Fabian, Messner, Ines, Uhl, Phoebe, Bond, Gregor, Puchhammer-Stoeckl, Elisabeth, Mueller-Sacherer, Thomas, Aufricht, Christoph, and Rusai, Krisztina
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CYTOMEGALOVIRUSES , *CYTOMEGALOVIRUS diseases , *VIRAL load , *KIDNEY transplantation , *TORQUE teno virus , *VIRUS diseases - Abstract
• Biomarkers for over- & underimmunosuppression are needed for pediatric KTX patients. • TTV plasma loads predict CMViremia & BKViremia one month before onset of viremia. • TTV cut-offs aid to stratify pediatric KTX patients at risk for CMV & BKV infection. : Long-term allograft and patient survival after kidney transplantation (KTX) depends on the balance between over- and under-immunosuppression (IS). High levels of IS predispose to opportunistic infections. Plasma load of Torque Teno Virus (TTV), a non-pathogenic highly prevalent Annellovirus, is associated with its hosts immune status, especially after solid organ transplantation. : To investigate the association of plasma TTV load and opportunistic viral infections after pediatric KTX. : This retrospective study includes all pediatric KTX patients followed at the Medical University of Vienna 2014–2020. PCR for Cytomegalovirus (CMV), Epstein-Barr virus (EBV), BK virus (BKV), and TTV was performed every 4–8 weeks at routine follow-up visits. : 71 pediatric KTX patients were followed with TTV measurements for a median of 2.7 years. TTV plasma load was associated with CMV DNAemia at the next visit with an OR of 2.37 (95 % CI 1.15–4.87; p = 0.03) after adjustment for time after KTX and recipient age. For a cut-off of 7.68 log10 c/mL TTV a sensitivity of 100 %, a specificity of 61 %, a NPV 100 %, and a PPV of 46 % to detect CMV DNAemia at the next visit was calculated. TTV plasma loads were also associated with BKV DNAuria and BKV DNAemia at the next visit, but not with EBV DNAemia. : This is the first study to analyse associations between TTV plasma loads and opportunistic viral infections in pediatric KTX. We were able to present a TTV cut-off for the prediction of clinically relevant CMV DNAemia that might be useful in clinical care. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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