1. Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency.
- Author
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Beyer KH Jr, Ward TD, Vary JE, Gelarden RT, Knutson DW, and Vesell ES
- Subjects
- Adult, Aged, Blood Glucose metabolism, Cholesterol blood, Electrolytes blood, Female, Guanidines blood, Humans, Hydrochlorothiazide blood, Male, Middle Aged, Pyrazines blood, Single-Blind Method, Triglycerides blood, Urea blood, Guanidines pharmacology, Hydrochlorothiazide pharmacology, Pyrazines pharmacology, Renal Insufficiency blood
- Abstract
A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency. Pyrazinoylguanidine was saluretic, without affecting serum potassium or glucose concentrations. The onset of PZG's antihypertensive effect occurred within 4 hours. In contrast, hydrochlorothiazide (HCTZ) increased serum concentrations of urea, triglycerides, and glucose, without affecting cholesterol.
- Published
- 1993
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