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Start Over Author "D Brass" Journal journal of clinical pathology
3 results on '"D Brass"'

1. Autoimmune pancytopenia following combination chemotherapy for chronic lymphocytic leukaemia: Figure 1

Author

Keith Gelly, D Brass, Sudhir Tauro, Mark Sales, Michael J. Groves, Stephanie F. MacCallum, and Joan Cunningham

Subjects
Evans syndrome, Cyclophosphamide, business.industry, Chronic lymphocytic leukemia, Combination chemotherapy, General Medicine, Haemolysis, medicine.disease, Pancytopenia, Autoimmune thrombocytopenia, Pathology and Forensic Medicine, Fludarabine, immune system diseases, hemic and lymphatic diseases, Immunology, medicine, business, medicine.drug
Abstract

Autoimmune haemolysis or thrombocytopenia can complicate purine nucleoside monotherapy for chronic lymphocytic leukaemia (CLL), but Evans syndrome is rare. This is a report of the occurrence of pancytopenia secondary to a unique combination of red cell aplasia with autoimmune thrombocytopenia and neutropenia in a patient with CLL following treatment with fludarabine and cyclophosphamide. This case is unusual for the simultaneous targeting of three haemopoietic lineages by immune dysfunction following fludarabine and cyclophosphamide, which is a treatment regimen believed to reduce autoimmune haematological toxicity in CLL.

Published
2009

2. Autoimmune pancytopenia following combination chemotherapy for chronic lymphocytic leukaemia

Author

S, MacCallum, M, Groves, D, Brass, J, Cunningham, M, Sales, K, Gelly, and S, Tauro

Subjects
Male, Pancytopenia, Antineoplastic Combined Chemotherapy Protocols, Humans, Middle Aged, Cyclophosphamide, Leukemia, Lymphocytic, Chronic, B-Cell, Vidarabine, Autoimmune Diseases
Abstract

Autoimmune haemolysis or thrombocytopenia can complicate purine nucleoside monotherapy for chronic lymphocytic leukaemia (CLL), but Evans syndrome is rare. This is a report of the occurrence of pancytopenia secondary to a unique combination of red cell aplasia with autoimmune thrombocytopenia and neutropenia in a patient with CLL following treatment with fludarabine and cyclophosphamide. This case is unusual for the simultaneous targeting of three haemopoietic lineages by immune dysfunction following fludarabine and cyclophosphamide, which is a treatment regimen believed to reduce autoimmune haematological toxicity in CLL.

Published
2009

3. Autoimmune pancytopenia following combination chemotherapy for chronic lymphocytic leukaemia.

Author

MacCallum S, Groves M, Brass D, Cunningham J, Sales M, Gelly K, and Tauro S

Subjects
Cyclophosphamide administration & dosage, Cyclophosphamide adverse effects, Humans, Male, Middle Aged, Vidarabine administration & dosage, Vidarabine adverse effects, Vidarabine analogs & derivatives, Antineoplastic Combined Chemotherapy Protocols adverse effects, Autoimmune Diseases chemically induced, Leukemia, Lymphocytic, Chronic, B-Cell drug therapy, Pancytopenia chemically induced
Abstract

Autoimmune haemolysis or thrombocytopenia can complicate purine nucleoside monotherapy for chronic lymphocytic leukaemia (CLL), but Evans syndrome is rare. This is a report of the occurrence of pancytopenia secondary to a unique combination of red cell aplasia with autoimmune thrombocytopenia and neutropenia in a patient with CLL following treatment with fludarabine and cyclophosphamide. This case is unusual for the simultaneous targeting of three haemopoietic lineages by immune dysfunction following fludarabine and cyclophosphamide, which is a treatment regimen believed to reduce autoimmune haematological toxicity in CLL.

Published
2009
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