1. Clinical, pathological, genetics and intratumoural immune milieu of micropapillary carcinoma of the colon
- Author
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Vikram Deshpande, Soo Hyun Lee, Andrew Crabbe, Amaya Pankaj, Azfar Neyaz, Yuho Ono, Steffen Rickelt, Swati Sonal, Cristina R Ferrone, David T Ting, Deepa Patil, Omer Yilmaz, David Berger, and Osman Yilmaz
- Subjects
General Medicine ,Pathology and Forensic Medicine - Abstract
AimMicropapillary carcinoma (MPC) is a recognised WHO variant of colonic carcinoma (CC), although little is known about its prognosis, immune microenvironment and molecular alterations. We investigated its clinical, pathological and immunological characteristics.MethodsWe assessed 903 consecutive CCs and used the WHO definition to identify MPC. We recorded serrated and mucinous differentiation and mismatch repair (MMR) status. We performed immunohistochemistry and quantification on tissue microarrays for HLA class I/II proteins, beta-2-microglobulin (B2MG), CD8, CD163, LAG3, PD-L1, FoxP3, PD-L1and BRAF V600E.ResultsWe classified 8.6% (N=78) of CC as MPC. Relative to non-MPC, MPC was more often high grade (p=0.03) and showed serrated morphology (pConclusionMPCs are associated with high-grade differentiation and a less active immune microenvironment than non-MPC. MPC is not associated with inferior disease-specific survival.
- Published
- 2023
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