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281 Background: There is controversy about the benefit of chemotherapy-induced amenorrhea (CIA) in breast cancer. We investigated significance of CIA after neoadjuvant chemotherapy for predicting response to neoadjuvant chemotherapy in breast cancer patients. Methods: We reviewed the records of 198 premenopausal patients with breast cancer treated with neoadjuvant chemotherapy between January 2005 and December 2010. Chemotherapy-induced amenorrhea (CIA) was defined as serum FSH level ≥40 IU/L after completion of all scheduled neoadjuvant chemotherapy and prior to definitive surgery. Results: Among 198 breast cancer patients, 132 pts (66.7%) developed CIA after neoadjuvant chemotherapy. 156 pts (78%) underwent DA chemotherapy. The age of CIA patients was older than non-CIA patients (41.55±5.55 vs. 38.27± 6.86 years, p=0.001). The incidence of CIA after neoadjuvant chemotherapy was significantly higher in responder group (responder vs. nonresponder: 87 pts (74.4%) vs. 45 pts (55.6%); p=0.006). Additionally, FSH level after all scheduled neoadjuvant chemotherapy was significantly higher in responder group (FSH 56.41±32.41 mIU/ml vs. 45.76±30.31 mIU/ml; p=0.021). In univariate analysis, CIA (p=0.006) and total number of chemotherapy cycle regardless of chemotherapy regimen (p=0.04) were significantly predictive of tumor response. CIA was only significant predictive factor for tumor response after neoadjuvant chemotherapy on multivariate analysis (p=0.012). Conclusions: CIA is independent predictive markers of response to neoadjuvant chemotherapy in locally advanced breast cancer.

5547 Background: Oral tongue squamous cell cancer (OTSCC) is one of the most aggressive subtypes in head and cancers. Currently, the most reliable prognostic indicator for OTSCC patients is the sta...

e15681 Background: To evaluate survival time and its prognostic factors contributing to survival of advanced unresected cholangiocarcinoma. Methods: We reviewed the experience of 330 patients with histologically proven unresected advanced intrahepatic and hilar cholangiocarcinoma and evaluated their survival time and significant prognostic factors. They did not receive any surgery, chemotherapy and radiotherapy and they underwent only palliative nonsurgical biliary drainage if it was needed to relieve biliary obstructive symptom. Results: Survival time of overall cholangiocarcinoma (median±SD) was 3.9±7.8 months; 3±5.3 months for intrahepatic cholangiocarcinoma, 5.9±10.1 months for hilar cholangiocarcinoma. By Kaplan-Meier survival analysis, intrahepatic cholangiocarcinoma patients survived significantly shorter than hilar cholangiocarcinoma patients. By multivariate analysis for intrahepatic cholangiocarcinoma, distant metastasis was independently associated with shorter survival time. Multivariate analysis for hilar cholangiocarcinoma showed initial CEA > 30 ng/dl were independent predictors of shorter survival. Conclusions: Patients with unresectable cholangiocarcinoma who do not undergo surgery, chemotherapy and/or radiotherapy have a dismal prognosis. We hope that the outcome of our study would help clinicians better predict the prognosis of cholangiocarcinoma patients not receiving such aggressive treatments. These data would be used as the comparable data for control groups of future studies to assess the outcome of newly designed or developed treatment method. No significant financial relationships to disclose.

4133 Background: BTC is an aggressive cancer with median survival time rarely exceeding 6 months. While most BTC is unresectable, there is currently no standard systemic chemotherapy. Recently, pha...

4061 Background: According to the recent studies, it is shown that the polymorphism of Interleukin 1β gene is associated with the incidence of gastric cancer caused by the Helicobacter pylori infec...

3545 Background: The interferon induced, dsRNA-activated, protein kinase (PKR) is a key regulator of translational initiation, and plays an important role in the regulation of cell proliferation, a...

4146 Background: Gastric cancer is the most common cancer in Korea. Adjuvant chemoradiation has become a standard of care in United States. We attempted to evaluate the efficacy and toxicity of FP ...

5549 Background: Low serum albumin concentrations have been associated with poorer than expected outcomes in a variety of malignant diseases. However, its value as a independent prognostic indicato...

4141 Background: Gastric cancer is the most common cancer in Korea. Adjuvant chemoradiation has become a standard of care in United States. We attempted to evaluate the efficacy and toxicity of FP ...

9664 Background uPAR has been known to play a major role in cancer invasion and metastasis. uPAR expression in various cancer type suggested poor prognosis. In hypoxic status, the expression of uPA...

4231 Background: The gastric cancer is one of the most common malignancies in Korea. Large number of patients had advanced disease or metastasis either at presentation or later. Chemotherapy is the...

3643 Background: The interferon induced, dsRNA-activated, protein kinase, PKR is a key regulator of translational initiation, playing an important role in the regulation of cell proliferation, apop...

9639 Background: Although Diffuse Large B-cell Lymphomas (DLBCL) is usually considered as a specific disease entity, findings suggest diversity rather than a single clinicopathological entity. Clinical prognostic systems, including the International Prognostic Index (IPI), is useful in assessing overall prognosis with some reserve. It is likely that the prognostic assessment of patients with DLBCL might be improved by using biological features. Methods: To determine the clinical significance and prognostic value of biological markers expressed in DLBCL, we retrospectively studied 26 patients diagnosed as de novo DLBCL at Chungnam National University Hospital.Immunohistochemical studies were performed with CD10, bcl-6, IRF-4, bcl-2, p16, Granzyme B, and MHC-II, Ki-67 antibodies on archival pathology specimens. Two immunophenotypic patterns were distinguished according to the pattern of differentiation: germinal center (GC; CD10±/Bcl-6+/IRF-4 −) or post–germinal center (pGC; CD10±/bcl-6±/ IRF4+)type. Result...