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Objective To explore the clinical value of dynamic intracranial pressure (ICP) monitoring combined with regional cerebral oxygen saturation (rSc02) monitoring target oriented therapy for severe traumatic brain injury (sTBI). Methods 60 patients with sTBI were randomly divided into dynamic ICP monitoring combined with rSc02 monitoring target oriented treatment group (combined monitoring group) and control group, with 30 cases in each group. The patients in the control group were treated under neurosurgical intensive care. The patients in the combined monitoring group were guided by ICP combined with rSc02 target monitoring on the basis of traditional intensive care treatment in neurosurgery. Results The Glasgow coma scale(GCS) score of patients in the combined monitoring group was higher than that in the control group. The GCS score of patients in the two groups was higher than that in the admission group, but the difference was not statistically significant (all P > 0. 05). The length of total hospital stay and the length of stay in neurosurgical intensive care unit (NSICU) in the combined monitoring group were significantly lower than those in the control group (P<0.05~0.01). At 6 months after discharge, the scores of modified Rankin Scale (mRS) and Glasgow prognosis scale (GOS) in the combined monitoring group were significantly better than those in the control group (P<0.05~0.01), and the mortality was significantly lower than that in the control group (P < 0. 05). Kaplan-Meier survival curve analysis showed that the survival time of patients in the combined monitoring group was significantly better than that in the control group (P < 0. 05). Conclusion ICP combined with rSc02 monitoring target oriented treatment can effectively shorten the total hospital stay and NSICU stay of sTBI patients, reduce the mortality and improve the prognosis of patients. [ABSTRACT FROM AUTHOR]