1. Electrodiagnostic Findings in Riboflavin Transporter Deficiency Type 2.
- Author
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Sanchez JA, Traub R, Trau SP, and Howard JF Jr
- Subjects
- Female, Homozygote, Humans, Mutation genetics, Riboflavin genetics, Bulbar Palsy, Progressive diagnosis, Bulbar Palsy, Progressive genetics, Hearing Loss, Sensorineural diagnosis, Hearing Loss, Sensorineural genetics
- Abstract
Abstract: We present the electrodiagnostic findings in a case of a 3-year-old girl presenting with sensory ataxia, gait disturbance, and visual-auditory disturbance with a genetically confirmed diagnosis of riboflavin transporter deficiency type 2 (RTD2). She carries a homozygous mutation in the SLC52A2 gene, c.1016T>C (p.Leu339Pro). Her testing demonstrates a non-length-dependent axonal sensorimotor polyneuropathy affecting predominantly the upper extremities with active denervation of the distal muscles of both arms. It is important to highlight these findings because most genetic neuropathies have a length-dependent pattern of involvement, affecting the distal legs before the arms. The electrodiagnostic findings in RTD2 have not been previously well described. These electrodiagnostic findings are in agreement with the typical clinical phenotype of RTD2, which affects the upper limbs and bulbar muscles more than the lower extremities., Competing Interests: The authors report no conflicts of interest., (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2022
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