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ABSTRACTTwenty-eight emm12-type Streptococcus pyogenesisolates from patients with invasive and noninvasive infections or from asymptomatic carriers were genetically typed. Sequencing of drs(distantly related sic[streptococcal inhibitor of complement]) genes identified two novel alleles and revealed a polymorphism for drssimilar to that of sic. No association was observed between the five different drsalleles and the five restriction patterns of the virregulon for the isolates studied. These data suggest that drssequencing may be useful for further differentiation of S. pyogenesisolates with emm12and identical virregulon restriction patterns.