1. Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant.
- Author
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Giani T, Arena F, Vaggelli G, Conte V, Chiarelli A, Henrici De Angelis L, Fornaini R, Grazzini M, Niccolini F, Pecile P, and Rossolini GM
- Subjects
- Bacteremia epidemiology, Bacteremia microbiology, Bacterial Proteins genetics, Cross Infection epidemiology, Cross Infection microbiology, Electrophoresis, Gel, Pulsed-Field, Genotype, Humans, Klebsiella Infections microbiology, Klebsiella pneumoniae drug effects, Klebsiella pneumoniae enzymology, Klebsiella pneumoniae genetics, Molecular Typing, Sequence Deletion, Anti-Bacterial Agents pharmacology, Bacterial Proteins metabolism, Colistin pharmacology, Disease Outbreaks, Drug Resistance, Bacterial, Klebsiella Infections epidemiology, Klebsiella pneumoniae isolation & purification, beta-Lactamases metabolism
- Abstract
We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption. The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant of an ST512 strain that produced KPC-3., (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
- Published
- 2015
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