1. Prosthetic Valve Endocarditis with Bartonella washoensis in a Human European Patient and Its Detection in Red Squirrels ( Sciurus vulgaris )
- Author
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K. Buschmann, Ankje de Vries, Matthew L. Aardema, Christof K. Seckert, Marja Kik, Elke Dauber, Friederike D. von Loewenich, Hein Sprong, and Moritz Brandstetter
- Subjects
0301 basic medicine ,Microbiology (medical) ,Fastidious organism ,Bartonella ,biology ,030106 microbiology ,Bartonella washoensis ,medicine.disease_cause ,medicine.disease ,biology.organism_classification ,rpoB ,Housekeeping gene ,Microbiology ,03 medical and health sciences ,030104 developmental biology ,medicine ,bacteria ,Endocarditis ,Multilocus sequence typing ,Sciurus - Abstract
Members of the genus Bartonella are fastidious Gram-negative facultative intracellular bacteria that are typically transmitted by arthropod vectors. Several Bartonella spp. have been found to cause culture-negative endocarditis in humans. Here, we report the case of a 75-year old German woman with prosthetic valve endocarditis due to Bartonella washoensis. The infecting agent was characterized by sequencing of six housekeeping genes (16S rRNA, ftsZ, gltA, groEL, ribC, rpoB) applying a multilocus sequence typing (MLST) approach. The 5097 bp of the concatenated housekeeping gene sequence from the patient were 99.0% identical to a B. washoensis strain from a red squirrel (Sciurus vulgaris orientis) from China. 39% (24/62) of red squirrel (S. vulgaris) samples from the Netherlands were positive for the B. washoensis gltA gene variant detected in the patient. This suggests that the red squirrel is the reservoir host for human infection in Europe.
- Published
- 2019