1. Association of neurotropic viruses in HIV-infected individuals who died of secondary complications of tuberculosis, cryptococcosis, or toxoplasmosis in South India.
- Author
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Kannangai R, Sachithanandham J, Mahadevan A, Abraham AM, Sridharan G, Desai A, Ravi V, and Shankar SK
- Subjects
- AIDS-Related Opportunistic Infections virology, Brain virology, Cerebrospinal Fluid virology, Cryptococcosis complications, DNA Virus Infections virology, DNA Viruses classification, DNA Viruses genetics, Humans, India epidemiology, Multiplex Polymerase Chain Reaction, Prevalence, Toxoplasmosis complications, Tuberculosis complications, AIDS-Related Opportunistic Infections mortality, Cryptococcosis mortality, DNA Virus Infections epidemiology, DNA Viruses isolation & purification, HIV Infections complications, Toxoplasmosis mortality, Tuberculosis mortality
- Abstract
The frequencies of 10 opportunistic DNA viruses were determined by multiplex real-time PCR in paired cerebrospinal fluid (CSF) and brain tissue of HIV-infected individuals. In the CSF, viruses were detectable in 45/55 cases: JC virus (JCV) in 62%, Epstein-Barr virus (EBV) in 44%, cytomegalovirus (CMV) in 25%, varicella-zoster virus (VZV) in 3.6%, herpes simplex virus 1 (HSV-1) in 1.8%, and human herpesvirus 6 (HHV-6) in 1.8% of cases. A single virus was detectable in 20 cases, 19 cases had coinfection with two viruses, and 6 cases were positive for three viruses. JCV was detectable in the CSF of 62% of cases and in 42% of brain tissues, with higher loads in progressive multifocal leukoencephalopathy (PML) (P < 0.05).
- Published
- 2013
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