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Background : Lower airway diseases in children are one of the major causes of hospitalisation. This study aimed to evaluate the characteristics of children admitted to a tertiary pediatric hospital diagnosed with lower airway disease and to identify differences between age groups and the two years of the study. Methods : In this single-centre retrospective observational study, demographic and clinical information about children hospitalised in the emergency pediatric ward and diagnosed with lower respiratory disease from 1 June 2021 to 30 June 2023 were retrospectively reviewed. Results : A total of 410 episodes of hospitalisation for lower airway diseases were registered. In 83.9% of cases, the patient needed hospitalisation for respiratory failure, and children <1 year of age were at higher risk. Rhinovirus and respiratory syncytial virus (RSV) were the leading causes of lower respiratory tract infections. No death has been recorded. In 8.8% of cases, the patient was admitted to the Pediatric Intensive Care Unit. In 2021-2022, we recorded more hospitalisations for bronchiolitis with RSV as the primary pathogen detected and more patients were admitted to the hospital for respiratory failure. In 2022-2023, we registered more admissions for bacterial pneumonia and the need for intravenous therapy. Conclusions : Lower respiratory tract diseases are frequent in the pediatric population, and the risk of respiratory failure is higher. Analysing the differences between the two years of study, we underline how the COVID-19 pandemic has changed the epidemiology of acute respiratory infections in children.

Background: Migraine is one of the most frequent primary headaches in childhood. The role of thrombotic predisposition in its pathogenesis is debated. Our aim was to analyse the cardiovascular risk factors and family history of major thrombotic events in children with migraine., Methods: A retrospective, single-centre study was performed over 12 years. Our headache centre record database was screened for migraine with aura (MA) and migraine without aura (MO) on the basis of the ICHD-II (until 2013) and III criteria. A control group of otherwise healthy children was recruited. Descriptive and multivariate analyses are provided; significance was set at p < 0.05., Results: Migraine was diagnosed in 930 children (24.7% MA); 73.3% were 9-14 years old. Children with MA were older ( p < 0.001). A family history of cerebral ischemic events at ≤50 years old was more commonly reported by children with MA than those with MO ( p < 0.001) and those in the control group ( p = 0.001). Children with MA showed a higher risk of a family history of cerebral ischemic events at ≤50 years old than children with MO (OR: 2.6) and those in the control group (OR: 3.1). When comparing the family history of DVT, we observed a significantly increased risk for MA vs. MO (OR: 2.9)., Conclusion: A family history of cerebral ischemic events at ≤50 years old leads to an increased risk of MA. Further studies are needed to explore such an association.