1. Increments in serum high-density lipoprotein cholesterol over time are not associated with improved outcomes in incident hemodialysis patients.
- Author
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Chang, Tae Ik, Streja, Elani, Soohoo, Melissa, Ko, Gang Jee, Rhee, Connie M, Kovesdy, Csaba P, Kashyap, Moti L, Vaziri, Nosratola D, Kalantar-Zadeh, Kamyar, and Moradi, Hamid
- Subjects
Humans ,Cardiovascular Diseases ,Renal Dialysis ,Incidence ,Cause of Death ,Proportional Hazards Models ,Cohort Studies ,Time Factors ,Aged ,Middle Aged ,Female ,Male ,Cholesterol ,HDL ,Outcome Assessment ,Health Care ,Dyslipidemia ,Hemodialysis ,High-density lipoprotein ,Lipid ,Mortality ,Atherosclerosis ,Cardiovascular ,Clinical Research ,Kidney Disease ,Zero Hunger ,Good Health and Well Being ,Medical Biochemistry and Metabolomics ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology - Abstract
BackgroundElevated serum high-density lipoprotein cholesterol (HDL-C) has not been associated with better cardiovascular (CV) and all-cause mortality in hemodialysis patients. However, the association between change in HDL over time and mortality has not been fully examined.ObjectiveIn a nationally representative cohort of incident hemodialysis patients who had available HDL data at baseline and 6 months after dialysis initiation, we studied the association of change in HDL-C during the first 6 months of dialysis with all-cause and CV mortality.MethodsAssociations between HDL-C change and mortality were determined in Cox proportional hazard regression models with adjustment for multiple variables.ResultsIn case-mix models, there was a J-shaped association between change in HDL-C and mortality, such that quartiles 1 (
- Published
- 2018