1. Assay methods for cyclosporine monitoring following liver transplantation
- Author
-
M. C. Haven, Linda Sobeski, Rodney S. Markin, and Robert A. Earl
- Subjects
Microbiology (medical) ,Graft Rejection ,medicine.medical_treatment ,Metabolite ,Clinical Biochemistry ,Radioimmunoassay ,Cyclosporins ,Pharmacology ,Liver transplantation ,chemistry.chemical_compound ,Immunology and Allergy ,Medicine ,Humans ,Chromatography, High Pressure Liquid ,Immunoassay ,medicine.diagnostic_test ,business.industry ,Clinical events ,Biochemistry (medical) ,Public Health, Environmental and Occupational Health ,Hematology ,Liver Transplantation ,Medical Laboratory Technology ,chemistry ,Therapeutic drug monitoring ,Evaluation Studies as Topic ,Fluorescence polarization immunoassay ,business - Abstract
This article reviews therapeutic drug monitoring for cyclosporine in liver transplantation. Brief descriptions of various immunoassay methods include sample matrix selection, assay reagents, and metabolite cross-reactivity information. Multiple comparisons of the various methods are outlined. Examples of the method-dependent relationship between clinical events and changes in cyclosporine concentration are presented. Other potential predictors of liver allograft function are listed.
- Published
- 1990