1. Prevalence of combined and noncombined dyslipidemia in an Iranian population
- Author
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Ali Asghar Mahmoudi, Maryam Saberi-Karimian, Majid Ghayour-Mobarhan, Susan Darroudi, Naghme Mokhber, Adeleh Mahdizadeh, Seyed Mohammad Reza Seyedzadeh Sani, Ali Motamedzadeh Torghabeh, Mahmoud Reza Azarpajouh, Maryam Tayefi, Habibollah Esmaeili, Mohammad Reza Parizadeh, Mahmoud Ebrahimi, Alireza Heidari-Bakavoli, Mohammad Safarian, Soheil Arekhi, Gordon A. Ferns, Mohsen Moohebati, and Amirhossein Sahebkar
- Subjects
Microbiology (medical) ,Adult ,Male ,medicine.medical_specialty ,Lipoproteins ,Clinical Biochemistry ,030204 cardiovascular system & hematology ,Iran ,Logistic regression ,Cohort Studies ,Diabetes Complications ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Prevalence ,Immunology and Allergy ,Medicine ,Humans ,030212 general & internal medicine ,Stroke ,Research Articles ,Dyslipidemias ,business.industry ,Biochemistry (medical) ,Public Health, Environmental and Occupational Health ,Hematology ,Middle Aged ,medicine.disease ,Medical Laboratory Technology ,Cardiovascular Diseases ,Population study ,lipids (amino acids, peptides, and proteins) ,Female ,Metabolic syndrome ,business ,Dyslipidemia ,QRISK ,Cohort study - Abstract
BACKGROUND: Combination of dyslipidemic phenotypes, including elevated plasma levels of low‐density lipoprotein cholesterol (LDL‐C), elevated plasma triglycerides (TG), and decreased low‐density lipoprotein cholesterol (HDL‐C) concentrations, is important because of the association of individual phenotypes with increased risk of cardiovascular disease (CVD). We investigated the prevalence of combined dyslipidemias and their effects on CVD risk in an Iranian large population. METHOD: A total of 9847 individuals were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. Anthropometric parameters and biochemical indices were measured in all of the subjects. Different types of combined dyslipidemias including high TG + low HDL‐C, high TG + low HDL‐C + high LDL‐C, low HDL‐C + high LDL‐C, high TG + high LDL‐C, and finally high TG + high LDL‐C + low HDL‐C were considered. Ten‐year CVD risk was calculated using the QRISK2 risk algorithm and adjustments were made as suggested by the Joint British Societies’ (JBS2). Logistic regression analyses were performed to determine the association between different combined dyslipidemias and categorical QRISK. RESULTS: A total of 3952 males and 5895 females were included in this current study. Among the included subjects, 83.4% had one form of dyslipidemia, and 16.6% subjects were not dyslipidemic. The mean age was 48.88 ± 7.9 and 47.02 ± 8.54 years for dyslipidemic and nondyslipidemic groups, respectively. The results showed that the frequency of dyslipidemia was 98%, 87.1%, and 90% in subjects with metabolic syndrome, CVD, and diabetes, respectively. Our results suggested that around 15.7% of study population were at 10 years CVD risk (high ≥20) and it was higher in men than women (P
- Published
- 2018