1. Exploiting bone niches: progression of disseminated tumor cells to metastasis.
- Author
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Muscarella AM, Aguirre S, Hao X, Waldvogel SM, and Zhang XH
- Subjects
- Bone Marrow Neoplasms immunology, Bone Marrow Neoplasms pathology, Bone Marrow Neoplasms secondary, Bone Neoplasms immunology, Bone Neoplasms pathology, Bone Remodeling immunology, Breast Neoplasms immunology, Breast Neoplasms pathology, Disease Progression, Female, Hematopoietic Stem Cells immunology, Hematopoietic Stem Cells pathology, Humans, Immune Privilege, Immune Tolerance, Male, Models, Biological, Myeloid Cells immunology, Neoplasm Metastasis immunology, Neoplasm Metastasis pathology, Neoplasm Metastasis therapy, Neoplastic Stem Cells immunology, Neoplastic Stem Cells pathology, Prostatic Neoplasms immunology, Prostatic Neoplasms pathology, Stem Cell Niche immunology, T-Lymphocytes, Regulatory immunology, Tumor Microenvironment immunology, Bone Neoplasms secondary
- Abstract
Many solid cancers metastasize to the bone and bone marrow (BM). This process may occur even before the diagnosis of primary tumors, as evidenced by the discovery of disseminated tumor cells (DTCs) in patients without occult malignancies. The cellular fates and metastatic progression of DTCs are determined by complicated interactions between cancer cells and BM niches. Not surprisingly, these niches also play important roles in normal biology, including homeostasis and turnover of skeletal and hematopoiesis systems. In this Review, we summarize recent findings on functions of BM niches in bone metastasis (BoMet), particularly during the early stage of colonization. In light of the rich knowledge of hematopoiesis and osteogenesis, we highlight how DTCs may progress into overt BoMet by taking advantage of niche cells and their activities in tissue turnover, especially those related to immunomodulation and bone repair.
- Published
- 2021
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