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Ｏｂjｅｃｔｉｖｅ　Ｔｏ ｉｎｖｅｓｔｉｇａｔｅ ｔｈｅ ｓｉｍｐｌｅ ｓｅｒｕｍ ｍａｒｋｅｒｓ ｆｏｒ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｉｎ ｃｈｒｏｎｉｃ ｈｅｐａｔｉｔｉｓ Ｂ （ＣＨＢ）ｐａｔｉｅｎｔｓ ｗｉｔｈ ａｎ ａｌａｎｉｎｅ ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ （ＡＬＴ）ｌｅｖｅｌ ｏｆ ＜2 ｔｉｍｅｓ ｕｐｐｅｒ ｌｉｍｉｔ ｏｆ ｎｏｒｍａｌ （ＵＬＮ）. Ｍｅｔｈｏｄｓ　Ｔｈｅ ｃｌｉｎｉｃａｌ ｄａｔａ ｏｆ 2７8 ＣＨＢ ｐａｔｉｅｎｔｓ ｗｉｔｈ ＡＬＴ ＜2 × ＵＬＮ （ＵＬＮ ＝40 Ｕ/ Ｌ）ｗｅｒｅ ａｎａｌｙｚｅｄ ｒｅｔｒｏｓｐｅｃｔｉｖｅｌｙ. Ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｗａｓ ｄｅｆｉｎｅｄ ａｓ ａ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｏｒｙ ａｃｔｉｖｉｔｙ ｇｒａｄｅ （Ｇ）≥2. Ｔｈｅ ｔ - ｔｅｓｔ ｗａｓ ｕｓｅｄ ｆｏｒ ｃｏｍｐａｒｉｓｏｎ ｏｆ ｎｏｒｍａｌｌｙ ｄｉｓｔｒｉｂｕｔｅｄ ｃｏｎｔｉｎｕｏｕｓ ｄａｔａ ｂｅｔｗｅｅｎ ｇｒｏｕｐｓ，ａｎｄ ｔｈｅ Ｋｒｕｓｋａｌ - Ｗａｌｌｉｓ ｒａｎｋ ｓｕｍ ｔｅｓｔ ｗａｓ ｕｓｅｄ ｆｏｒ ｎｏｎ - ｎｏｒｍａｌｌｙ ｄｉｓｔｒｉｂｕｔｅｄ ｃｏｎｔｉｎｕｏｕｓ ｄａｔａ；ｔｈｅ ｃｈｉ - ｓｑｕａｒｅ ｔｅｓｔ ｗａｓ ｕｓｅｄ ｆｏｒ ｃｏｍｐａｒｉｓｏｎ ｏｆ ｃａｔｅｇｏｒｉｃａｌ ｄａｔａ ｂｅｔｗｅｅｎ ｇｒｏｕｐｓ. Ｍｕｌｔｉｖａｒｉａｔｅ ｌｏｇｉｓｔｉｃ ｒｅｇｒｅｓｓｉｏｎ ａｎａｌｙｓｉｓ ｗａｓ ｕｓｅｄ ｔｏ ｉｄｅｎｔｉｆｙ ｉｎｄｅｐｅｎｄｅｎｔ ｐｒｅｄｉｃｔｏｒｓ ｆｏｒ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｉｎ ＣＨＢ ｐａｔｉｅｎｔｓ ｗｉｔｈ ＡＬＴ ＜2 × ＵＬＮ. Ｔｈｅ ｒｅｃｅｉｖｅｒ ｏｐｅｒａｔｉｎｇ ｃｈａｒａｃｔｅｒｉｓｔｉｃ （ＲＯＣ）ｃｕｒｖｅ ｗａｓ ｕｓｅｄ ｔｏ ｅｖａｌｕａｔｅ ｔｈｅ ｄｉａｇｎｏｓｔｉｃ ｖａｌｕｅ ｏｆ ｓｅｒｕｍ ｍａｒｋｅｒｓ ｉｎ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ. Ｒｅｓｕｌｔｓ　Ｏｆ ｔｈｅ 2７8 ＣＨＢ ｐａｔｉｅｎｔｓ ｅｎｒｏｌｌｅｄ，1７５ （62. ９％ ）ｈａｄ ｎｏ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ （Ｇ0 - 1 ｇｒｏｕｐ）ａｎｄ 103 （3７. 1％ ）ｈａｄ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ （Ｇ2 - 4 ｇｒｏｕｐ）. Ｔｈｅｒｅ ｗｅｒｅ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅｓ ｉｎ ＡＬＴ，ａｓｐａｒｔａｔｅ ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ，ａｌｋａｌｉｎｅ ｐｈｏｓｐｈａｔａｓｅ，ｇａｍｍａ - ｇｌｕｔａｍｙｌ ｔｒａｎｓｐｅｐｔｉｄａｓｅ （ＧＧＴ），ａｌｂｕｍｉｎ，ｇｌｏｂｕｌｉｎ，ｐｒｏｔｈｒｏｍｂｉｎ ｔｉｍｅ （ＰＴ），ｐｌａｔｅｌｅｔ，ａｂｓｏｌｕｔｅ ｎｅｕｔｒｏｐｈｉｌ ｃｏｕｎｔ，ｈｙａｌｕｒｏｎｉｃ ａｃｉｄ （ＨＡ），ｇｌｙｃｏｃｈｏｌｉｃ ａｃｉｄ，ｐｒｅｃｏｌｌａｇｅｎ Ⅲ，ａｎｄ ｃｏｌｌａｇｅｎ ｔｙｐｅ Ⅳ（ⅣＣ）ｂｅｔｗｅｅｎ ｔｈｅ ｔｗｏ ｇｒｏｕｐｓ （ａｌｌ Ｐ ＜0. 0５）. Ｔｈｅ ｍｕｌｔｉｖａｒｉａｔｅ ｒｅｇｒｅｓｓｉｏｎ ａｎａｌｙｓｉｓ ｓｈｏｗｅｄ ｔｈａｔ ＧＧＴ，ＰＴ，ⅣＣ，ａｎｄ ＨＡ ｗｅｒｅ ｉｎｄｅｐｅｎｄｅｎｔ ｐｒｅｄｉｃｔｏｒｓ ｆｏｒ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｉｎ ＣＨＢ ｐａｔｉｅｎｔｓ ｗｉｔｈ ＡＬＴ ＜2 × ＵＬＮ （ＯＲ ＝1. 01５，1. 600，1. 1５1，ａｎｄ 1. 014，Ｐ ＝0. 008，0. 021，0. 003，ａｎｄ 0. 018）. Ｔｈｅ ａｒｅａｓ ｕｎｄｅｒ ｔｈｅ ＲＯＣ ｃｕｒｖｅ ｆｏｒ ＧＧＴ，ＰＴ，ＩＶＣ，ａｎｄ ＨＡ ｔｏ ｄｉａｇｎｏｓｅ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｗｅｒｅ 0. 804，0. ７22，0. ７0７，ａｎｄ 0. 632，ｒｅｓｐｅｃｔｉｖｅｌｙ. Ｔｈｅ ｃｕｔ - ｏｆｆ ｖａｌｕｅ ｏｆ 48. ５ Ｕ/ Ｌ ｆｏｒ ＧＧＴ ｔｏ ｐｒｅｄｉｃｔ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｈａｄ ａ ｓｐｅｃｉｆｉｃｉｔｙ ｏｆ ９0. 3％ ａｎｄ ａ ｎｅｇａｔｉｖｅ ｐｒｅｄｉｃｔｉｖｅ ｖａｌｕｅ ｏｆ ７4. 6％ . Ｃｏｎｃｌｕｓｉｏｎ　ＧＧＴ，ＰＴ，ＩＶＣ，ａｎｄ ＨＡ ａｒｅ ｉｎｄｅｐｅｎｄｅｎｔ ｐｒｅｄｉｃｔｏｒｓ ｆｏｒ ｓｉｇｎｉｆｉｃａｎｔ ｌｉｖｅｒ ｉｎｆｌａｍｍａｔｉｏｎ ｉｎ ＣＨＢ ｐａｔｉｅｎｔｓ ｗｉｔｈ ＡＬＴ ＜2 × ＵＬＮ，ａｍｏｎｇ ｗｈｉｃｈ ＧＧＴ ｈａｓ ｔｈｅ ｈｉｇｈｅｓｔ ｐｒｅｄｉｃｔｉｖｅ ｖａｌｕｅ. [ABSTRACT FROM AUTHOR]

There are about 150 million people around the world with chronic hepatitis C virus (HCV) infection currently, of whom 20% will ultimately progress to cirrhosis and eventually die of end - stage liver disease and hepatocellular carcinoma. Interferon (IFN) has long been recognized as the cornerstone of the treatment of chronic hepatitis C because of its role in sustained virologic response and prevention of disease progression. However, it has limited efficacy and multiple adverse effects. In recent years, direct - acting antiviral agents (DAAs) have shown good efficacy. This review summarizes the recent advances in IFN - free anti - HCV therapeutic regimens based on DAAs. We believe that, with the emergence of DAAs , IFN - free therapies will develop rapidly and display better prospects. [ABSTRACT FROM AUTHOR]