1. Semantic fluency and processing speed are reduced in non-cognitively impaired participants with Parkinson’s disease
- Author
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Cholerton, Brenna A, Poston, Kathleen L, Yang, Laurice, Rosenthal, Liana S, Dawson, Ted M, Pantelyat, Alexander, Edwards, Karen L, Tian, Lu, Quinn, Joseph F, Chung, Kathryn A, Hiller, Amie L, Hu, Shu-Ching, Montine, Thomas J, and Zabetian, Cyrus P
- Subjects
Biological Psychology ,Psychology ,Acquired Cognitive Impairment ,Neurosciences ,Behavioral and Social Science ,Clinical Research ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Dementia ,Neurodegenerative ,Clinical Trials and Supportive Activities ,Parkinson's Disease ,Brain Disorders ,Aging ,Neurological ,Cognition ,Cognitive Dysfunction ,Humans ,Neuropsychological Tests ,Parkinson Disease ,Semantics ,cognition ,healthy volunteers ,neuropsychological assessment ,Parkinson's disease ,Parkinson’s disease ,Cognitive Sciences ,Experimental Psychology ,Biological psychology ,Clinical and health psychology ,Cognitive and computational psychology - Abstract
Introduction: Parkinson's disease (PD) is associated with a range of cognitive deficits. Few studies have carefully examined the subtle impacts of PD on cognition among patients who do not meet formal criteria for MCI or dementia. The aim of the current study was thus to describe the impact of PD on cognition in those without cognitive impairment in a well-characterized cohort.Methods: Non-cognitively impaired participants (122 with PD, 122 age- and sex-matched healthy volunteers) underwent extensive cognitive testing. Linear regression analyses compared diagnostic group performance across cognitive measures. For cognitive tasks that were significantly different between groups, additional analyses examined group differences restricting the group inclusion to PD participants with mild motor symptoms or disease duration less than 10 years.Results: Processing speed and semantic verbal fluency were significantly lower in the PD group (B = -3.77, 95% CIs [-5.76 to -1.77], p
- Published
- 2021