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With the escalating generation of municipal solid waste (MSW) and the increasing utilization of collection and transportation (C&T) vehicles within the MSW classification system, the associated costs and greenhouse gas (GHG) emissions from waste drop-off, as well as the C&T processes, have risen sharply. However, the mesoscopic view of the waste drop-off and C&T system is limited. Therefore, we divided the waste classification management (WCM) system into three subsystems: generation and drop-off, C&T, and disposal. Based on system dynamics theory, the logical relationships between relevant parameters in each subsystem were established. A WCM system dynamics model, which focused mainly on the drop-off and C&T processes, was constructed using Anylogic software. Using sensitivity, scenario, and uncertainty analyses, the economic impact and GHG emissions of the WCM system were analyzed in detail. The results showed that the waste drop-off and C&T processes accounted for 54.29–57.87% ($47.31 per ton) and 24.54–26.83% ($21.39–21.93 per ton) of the total cost in the whole waste management chain, respectively. GHG emissions were mainly generated in disposal facilities (116.84–257.86 kg CO 2 -eq/t), followed by C&T (19.02–20.55 kg CO 2 -eq/t) and drop-off processes (12.68–18.78 kg CO 2 -eq/t). The system cost and GHG emissions were significantly influenced by the components of the source-separated waste and operational parameters of the applied C&T vehicles. This study not only provides a basis for WCM policy formulation but also a tool for the design and optimization of waste C&T systems. • A system dynamics model was developed for waste classification management. • Collection and transportation sections cost $64.99–72.48/tMSW. • Vehicle operation significantly impacts cost and GHG emissions. • Electric vehicles have limited advantages. [ABSTRACT FROM AUTHOR]