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Start Over Author "Mizuno, Ryoko" Journal journal of chromatography b: analytical technologies in the biomedical & life sciences
1 results on '"Mizuno, Ryoko"'

1. Quantification of serum C-peptide by isotope-dilution liquid chromatography–tandem mass spectrometry: Enhanced detection using chemical modification and immunoaffinity purification.

Author

Kinumi, Tomoya, Mizuno, Ryoko, and Takatsu, Akiko

Subjects
*BLOOD proteins, *BLOOD serum analysis, *C-peptide, *ISOTOPE dilution analysis, *LIQUID chromatography-mass spectrometry, *TANDEM mass spectrometry, *CHEMICAL modification of proteins, *IMMUNOAFFINITY chromatography
Abstract

Highlights: [•] We developed a highly sensitive method for quantification of serum C-peptide. [•] This method is based on isotope-dilution mass spectrometry. [•] We applied chemical modification and immunoaffinity purification to this method. [•] These resulted in a 23-fold enhancement of the sensitivity. [•] This method enables high sensitivity and precision covering the reference interval. [ABSTRACT FROM AUTHOR]

Published
2014
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