1. Comparative Outcomes in Children and Adults With Anti- N-Methyl-D-Aspartate (anti-NMDA) Receptor Encephalitis
- Author
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Deanna Saylor, Anusha K. Yeshokumar, John C. Probasco, Ana Arenivas, and Eliza Gordon-Lipkin
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Standard score ,Severity of Illness Index ,Interviews as Topic ,03 medical and health sciences ,Disability Evaluation ,Young Adult ,0302 clinical medicine ,Interquartile range ,Severity of illness ,Medicine ,Humans ,030212 general & internal medicine ,Young adult ,Age of Onset ,Retrospective Studies ,Anti-NMDA receptor encephalitis ,Anti-N-Methyl-D-Aspartate Receptor Encephalitis ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Physical therapy ,Female ,Neurology (clinical) ,Age of onset ,business ,030217 neurology & neurosurgery ,Encephalitis ,Follow-Up Studies - Abstract
This study compared neurologic disability and adaptive function in children and adults >1 year following anti- N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis diagnosis. Retrospective record review identified 12 patients with anti-NMDAR encephalitis. At last follow-up, all surviving patients had “good” modified Rankin Score (0-2). Four children, 6 adults, and their families participated in a telephone interview. Median duration since diagnosis was similar for children (2.42 years, interquartile range 2.12-3.32) and adults (3.55 years, interquartile range 2.08-5.50 years). 3/4 (75%) pediatric and 3/5 (60%) adult patients reported neuropsychiatric symptoms (fatigue, emotional lability, short-term memory deficits or concentration deficits). On the Adaptive Behavior Assessment System (ABAS-3), although overall adaptive function was intact for adults (general adaptive composite standard score: median 104.5, interquartile range 98.8-112.5), the median for children was below average (General Adaptive Composite Standard Score: median 82.0, interquartile range 79.0-89.0). Children with anti-NDMAR encephalitis may have long-term effects impacting daily life while adults regain normal function.
- Published
- 2017