Untreated or inadequately treated domestic wastewater has adversely affected the aquatic environment and public health in many cities in Vietnam. A conventional anaerobic–anoxic–oxic (AAO) process is recognized as an easy-to-handle approach that constrains chemical use during the procedure. Herein, we improve an AAO system by adding more oxic orders in association with a biological membrane in order to increase the hydraulic retention time (HRT) of the oxic zone in the system. The investigated system was applied to the treatment of real domestic wastewater during 168 days of operation. The performance of the system reached a stable state after 60 days of operation. The removal efficiency of total nitrogen (TN), total phosphorus (TP), total suspended solids (TSS), biological oxygen demand (BOD5), and chemical oxygen demand (COD) was found to be 93.6 ± 3.0%, 91.9 ± 3.5%, 88.6 ± 1.2%, 82.6 ± 1.4%, and 71.8 ± 0.7%, respectively. After the operation process, the TN, TP, and TSS contents in the wastewater effluents met the A level in accordance with the QCVN 14-MT:2015/BTNMT regulation, and the effluents of COD and BOD5 almost satisfied the requirement, with only some points being slightly higher than the limit values. The obtained data revealed that the AAO/O system was capable of treating domestic wastewater in small and medium-sized domestic wastewater treatment facilities. more...