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Your search keyword '"Matsumoto, Masayasu"' showing total 18 results
Start Over Author "Matsumoto, Masayasu" Journal journal of cerebral blood flow & metabolism
18 results on '"Matsumoto, Masayasu"'

18. Preserved acetazolamide reactivity in lacunar patients with severe white-matter lesions: 15O-labeled gas and H2O positron emission tomography studies.

Author

Nezu, Tomohisa, Yokota, Chiaki, Uehara, Toshiyuki, Yamauchi, Miho, Fukushima, Kazuhito, Toyoda, Kazunori, Matsumoto, Masayasu, Iida, Hidehiro, and Minematsu, Kazuo

Subjects
CEREBRAL arterial diseases, ACETAZOLAMIDE, POSITRON emission tomography, OXYGEN in the blood, HEMODYNAMICS, CEREBROVASCULAR disease patients, CEREBRAL circulation
Abstract

Limited evidence exists on the relationships between severity of white-matter lesions (WMLs) and cerebral hemodynamics in patients without major cerebral artery disease. To examine changes of cerebral blood flow (CBF), oxygen metabolism, and vascular reserve capacity associated with severity of WML in patients with lacunar stroke, we used a positron emission tomography (PET). Eighteen lacunar patients were divided into two groups according to the severity of WMLs, assessed by Fazekas classification; grades 0 to 1 as mild WML group and grades 2 to 3 as severe WML group. Rapid dual autoradiography was performed with 15O-labeled gas-PET followed by 15O-labeled water-PET with acetazolamide (ACZ) challenge. Compared with the mild WML group, the severe WML group showed lower CBF (20.6±4.4 versus 29.9±8.2 mL/100 g per minute, P=0.008), higher oxygen extraction fraction (OEF) (55.2±7.4 versus 46.7±5.3%, P=0.013), and lower cerebral metabolic rate of oxygen (CMRO2) (1.95±0.41 versus 2.44±0.42 mL/100 g per minute, P=0.025) in the centrum semiovale. There were no significant differences in the ACZ reactivity between the two groups (48.6±22.6% versus 42.5±17.2%, P=0.524). Lacunar patients with severe WMLs exhibited reduced CBF and CMRO2, and increased OEF in the centrum semiovale. The ACZ reactivity was preserved in both patients with severe and mild WMLs in each site of the brain. [ABSTRACT FROM AUTHOR]

Published
2012
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