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The tumor‐suppressive role of microRNA‐216a‐3p (miR‐216a‐3p) has been evidenced in multiple tumors. Yet, the relevance of miR‐216a‐3p in cervical cancer remains undermined. The current study was designed to determine the expression and potential function of miR‐216a‐3p in cervical cancer. Expression of miR‐216a‐3p was markedly decreased in cervical cancer and functional assays revealed an inhibitory effect of miR‐216a‐3p on the proliferation, colony formation, and invasion of cervical cancer. Actin‐like 6A (ACTL6A) was identified as a target gene of miR‐216a‐3p. Elevated ACTL6A expression was detected in cervical cancer, and ACTL6A inhibition exhibited a tumor‐suppressive effect. ACTL6A inhibition increased yes‐associated protein (YAP) phosphorylation and downregulated YAP‐mediated transcriptional activity. ACTL6A restoration or YAP reactivation partially abrogated the miR‐216a‐3p‐mediated antitumor effect in cervical cancer cells. Taken together, these data demonstrate that miR‐216a‐3p acts as a potential tumor‐suppressive miRNA in cervical cancer, which exerts its function through inhibition of YAP signaling via targeting ACTL6A. [ABSTRACT FROM AUTHOR]