1. Developments in the study of gastrointestinal microbiome disorders affected by FGF19 in the occurrence and development of colorectal neoplasms
- Author
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Liang Xinyun, Yi Zhao, Peiqi Liu, Min Zhang, Qiaowen Zheng, Meichang Peng, and Wang Yan
- Subjects
0301 basic medicine ,Physiology ,Clinical Biochemistry ,Ileum ,Inflammation ,Fibroblast growth factor ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,medicine ,Humans ,Microbiome ,business.industry ,Gastrointestinal Microbiome ,FGF19 ,Cell Biology ,medicine.disease ,Fibroblast Growth Factors ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cancer research ,medicine.symptom ,business ,Colorectal Neoplasms ,Hormone - Abstract
Colorectal neoplasms are a type of malignant digestive system tumor that has become the third-highest morbidity tumor in China and the fourth leading cause of cancer-related death worldwide. The role of the gastrointestinal (GI) microbiome in bile acid metabolism, inflammation, and insulin resistance and its strong correlation with the occurrence and development of colorectal neoplasms have gradually led to it becoming a target area of tumor research. Fibroblast growth factor (FGF) 19 is a hormone that is secreted in mainly the ileum and can regulate bile acid biosynthesis, improve inflammation, and regulate insulin resistance. The relationship of the GI microbiome, FGF19 and its carcinogenic activities in colorectal neoplasms enticed us to search for potential targets and research ideas for the clinical diagnosis and treatment of colorectal neoplasms.
- Published
- 2019