1. LncRNA-CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA-215.
- Author
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Kong X, Duan Y, Sang Y, Li Y, Zhang H, Liang Y, Liu Y, Zhang N, and Yang Q
- Subjects
- Breast Neoplasms genetics, Breast Neoplasms pathology, Cell Cycle Proteins genetics, Disease Progression, Female, G1 Phase Cell Cycle Checkpoints, Gene Expression Regulation, Neoplastic, Humans, MCF-7 Cells, MicroRNAs genetics, Neoplasm Invasiveness, Nuclear Proteins genetics, RNA, Long Noncoding genetics, Signal Transduction, Breast Neoplasms metabolism, Cell Cycle Proteins metabolism, Cell Movement, Cell Proliferation, MicroRNAs metabolism, Nuclear Proteins metabolism, RNA, Long Noncoding metabolism
- Abstract
Rapid proliferation and metastasis of breast cancers resulted in poor prognosis in clinic. Recent studies have proved that long noncoding RNAs (lncRNAs) were involved in tumor progression. In this study, we aimed to determine the roles and mechanisms of lncRNA-cell division cycle 6 (CDC6) in regulating proliferation and metastasis of breast cancer. Clinically, lncRNA-CDC6 was highly expressed in tumor tissues and was positively correlated with clinical stages of breast cancers. Functionally, the ectopic expression of lncRNA-CDC6 promoted proliferation via regulation of G1 phase checkpoint, and further promoting the migration capability. Moreover, lncRNA-CDC6 could function as competitive endogenous RNA (ceRNA) via directly sponging of microRNA-215 (miR-215), which further regulating the expression of CDC6. Taken together, our results proved that lncRNA-CDC6 could function as ceRNA and promote the proliferation and metastasis of breast cancer cells, which provided a novel prognostic marker for breast cancers in clinic., (© 2018 Wiley Periodicals, Inc.)
- Published
- 2019
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