1. Circulating microRNA-133, microRNA-17 and microRNA-25 in serum and its potential diagnostic value in gastric cancer.
- Author
-
ZiaSarabi P, Sorayayi S, Hesari A, and Ghasemi F
- Subjects
- Adult, Aged, Biomarkers, Tumor genetics, Case-Control Studies, Circulating MicroRNA genetics, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Male, MicroRNAs genetics, Middle Aged, Prognosis, ROC Curve, Stomach Neoplasms genetics, Biomarkers, Tumor blood, Circulating MicroRNA blood, MicroRNAs blood, Stomach Neoplasms blood, Stomach Neoplasms pathology
- Abstract
Gastric cancer is one of the most common malignancies in the world and is considered as the most lethal gastrointestinal cancer. microRNAs (miRNAs) can be very important in detecting a disease at an early stage. The aim of this study was to investigate the microRNA-17 (miR-17), miR-25, and miR-133b in the serum of gastric cancer subjects. Serum samples were obtained from 120 gastric cancers and 102 healthy subjects. We evaluated expression levels of miR-17, miR-25 and miR-133b by quantitative real-time polymerase chain reaction. Our results showed that in the patients with gastric cancer, the expression level of miR-17 and miR-25 were significantly increased compared with the control group (P < 0.5), while the expression level of miR-133b was significantly decreased in patient groups compared with control cases (P < 0.5). It seems that expression of miRNAs in Iranian patients with gastric cancer is similar to other patients in other populations. These findings suggested that miR-17, miR-25 and miR-133b could be introduced as potential diagnostic candidates for the detection in gastric cancer patients in the early stage., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
- Full Text
- View/download PDF