Search

Your search keyword '"Zhao,Chengguang"' showing total 5 results
Start Over Author "Zhao,Chengguang" Journal journal of cellular and molecular medicine
5 results on '"Zhao,Chengguang"'

3. Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines and in a mouse model

Author

Yin, Changtian, primary, Dai, Xuanxuan, additional, Huang, Xiangjie, additional, Zhu, Wangyu, additional, Chen, Xi, additional, Zhou, Qiulin, additional, Wang, Canwei, additional, Zhao, Chengguang, additional, Zou, Peng, additional, Liang, Guang, additional, Rajamanickam, Vinothkumar, additional, Wang, Ouchen, additional, Zhang, Xiaohua, additional, and Cui, Ri, additional

Published
2019
Full Text
View/download PDF

4. Gracillin shows potent efficacy against colorectal cancer through inhibiting the STAT3 pathway.

Author

Yang L, Zhu T, Ye H, Shen Y, Li Z, Chen L, Wang C, Chen X, Zhao H, Xiang Y, Xiao Z, Zhao C, Li J, and Hu W

Subjects
Animals, Apoptosis drug effects, Cell Line, Tumor, Cell Proliferation drug effects, Female, Gene Expression Regulation, Neoplastic drug effects, Gene Expression Regulation, Neoplastic genetics, HCT116 Cells, Humans, Mice, Mice, Inbred BALB C, Mice, Nude, STAT3 Transcription Factor metabolism, Signal Transduction drug effects, Wound Healing drug effects, Xenograft Model Antitumor Assays, Colorectal Neoplasms drug therapy, Colorectal Neoplasms metabolism, Spirostans pharmacology, Spirostans therapeutic use
Abstract

Colorectal cancer (CRC) accounts for about 10% of all annually diagnosed cancers and cancer-related deaths worldwide. STAT3 plays a vital role in the occurrence and development of tumours. Gracillin has shown a significant antitumour activity in tumours, but its mechanism remains unknown. The human CRC cell lines HCT116, RKO, and SW480 and immunodeficient mice were used as models to study the effects of gracillin on cell proliferation, migration and apoptosis. These were evaluated by cell viability, colony formation, wound-healing migration and cell apoptosis assays. Luciferase reporter assay, and immunostaining and western blot analyses were used to explore the specific mechanism through which gracillin exerts its effects. Gracillin significantly reduces viability and migration and stimulates apoptosis in human CRC cells. It also significantly inhibits tumour growth with no apparent physiological toxicity in animal model experiments. Moreover, gracillin is found to inhibit STAT3 phosphorylation and STAT3 target gene products. In addition, gracillin inhibits IL6-induced nuclear translocation of P-STAT3. Gracillin shows potent efficacy against CRC by inhibiting the STAT3 pathway. It should be further explored as a unique STAT3 inhibitor for the treatment of CRC., (© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)

Published
2021
Full Text
View/download PDF

5. Down-regulation of MTHFD2 inhibits NSCLC progression by suppressing cycle-related genes.

Author

Yu C, Yang L, Cai M, Zhou F, Xiao S, Li Y, Wan T, Cheng D, Wang L, Zhao C, and Huang X

Subjects
Aminohydrolases metabolism, Animals, Apoptosis genetics, Carcinogenesis genetics, Carcinogenesis pathology, Cell Line, Tumor, Cell Proliferation genetics, Disease Progression, Female, Gene Expression Profiling, Gene Knockdown Techniques, Humans, Methylenetetrahydrofolate Dehydrogenase (NADP) metabolism, Mice, Inbred BALB C, Mice, Nude, Multifunctional Enzymes metabolism, Oncogenes, RNA, Messenger genetics, RNA, Messenger metabolism, Up-Regulation genetics, Aminohydrolases genetics, Carcinoma, Non-Small-Cell Lung genetics, Carcinoma, Non-Small-Cell Lung pathology, Cell Cycle genetics, Down-Regulation genetics, Gene Expression Regulation, Neoplastic, Lung Neoplasms genetics, Lung Neoplasms pathology, Methylenetetrahydrofolate Dehydrogenase (NADP) genetics, Multifunctional Enzymes genetics
Abstract

Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a bifunctional enzyme located in the mitochondria. It has been reported to be overexpressed in several malignancies. However, the relationship between the expression of MTHFD2 and non-small cell lung cancer (NSCLC) remains largely unknown. In this study, we found that MTHFD2 was significantly overexpressed in NSCLC tissues and cell lines. Knockdown of MTHFD2 resulted in reduced cell growth and tumorigenicity in vitro and in vivo. Besides, the mRNA and protein expression level of cell cycle genes, such as CCNA2, MCM7 and SKP2, was decreased in MTHFD2 knockdown H1299 cells. Our results indicate that the inhibitory effect of MTHFD2 knockdown on NSCLC may be mediated via suppressing cell cycle-related genes. These findings delineate the role of MTHFD2 in the development of NSCLC and may have potential applications in the treatment of NSCLC., (© 2019 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results