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The article discusses the challenges faced by researchers in the process of publishing their scientific papers. It highlights the difficulties of getting papers accepted by journals, the overwhelming workload of reviewers, and the decreasing readership of published papers. The author suggests that the current system of publishing needs to be reformed and proposes the idea of providing salary support for reviewers to ensure timely and fair reviews. The article concludes by emphasizing the need for a discussion on improving the review and publication process. [Extracted from the article]

The article discusses the challenges and frustrations faced by researchers in the publishing process. The author reflects on the increasing difficulty of finding reviewers and the harshness of their feedback. They propose that papers have become a form of currency, with researchers exchanging publications for career advancement and recognition. The author suggests that the current system may not be sustainable and explores potential solutions. [Extracted from the article]

The article features an interview with Danielle Buglak and Kathleen Holmes, the co-first authors of a paper titled "The proximal centriole-like structure maintains nucleus-centriole architecture in sperm." The study focuses on the architecture of the sperm's neck and its role in connecting the head and tail. Using the fruit fly Drosophila as a model system, the researchers discovered that the sperm's neck develops multiple points of attachment to the head, which are crucial for stability and fertility. The authors also discuss the challenges they faced during the project and their motivations for pursuing a career in science. [Extracted from the article]

The article features an interview with Xiaohuan Sun, the first author of a paper on the antagonistic roles of tau and MAP6 in regulating neuronal development. The study explores how these proteins interact with microtubules in neurons, affecting growth and shape. By reducing tau and MAP6 levels in rodent neurons, the researchers observed changes in growth, migration, and branching, highlighting the importance of balancing these proteins for healthy neuron function. The findings provide insights into neurodegenerative diseases like Alzheimer's. [Extracted from the article]

The article features an interview with Emmet Francis, the first author of a paper titled "Computational modeling establishes mechanotransduction as a potent modulator of the mammalian circadian clock" published in the Journal of Cell Science. The paper discusses the integration of a cell's response to mechanical cues with its intrinsic circadian clock using a mathematical model. The simulations show that increased mechanical activation can alter the period and amplitude of circadian oscillations and even eliminate them in certain cases. The findings have implications for diseases associated with changes in cell and tissue mechanical properties and tissues that experience strain. [Extracted from the article]

This document is an interview with Kairbaan Hodivala-Dilke, a Professor of Tumour Microenvironment at Barts Cancer Institute in London. She discusses her career path and what inspired her to become a scientist, including her early interest in nature and biology. She also talks about her research focus on understanding the roles of cell adhesion and angiocrine signaling in cancer and responses to therapy. Additionally, she mentions her interest in studying the relationship between ethnicity and cancer treatment efficacy. The article discusses the need to address the lack of diversity in clinical trials for standard-of-care drugs, which have primarily been conducted on white people. The author emphasizes the importance of understanding stroma-tumor cell interactions in different ethnic groups to develop more effective treatment strategies for cancer. They also discuss the challenges and rewards of translational research and the role of leadership in science. The author expresses their interest in joining the Journal of Cell Science community and highlights the need for papers that present significant discoveries and new understandings in cell biology. They also advocate for shorter papers and emphasize the importance of reading and understanding the fundamentals of research. The author concludes by sharing their philosophy of enabling and supporting others and their love for cooking and good chocolate. [Extracted from the article]

The article discusses the challenges faced by actors in the entertainment industry and draws parallels to the dissemination of scientific research in the biomedical field. It highlights the unfairness and difficulties actors face in securing roles and the financial struggles they often experience. The author proposes ways to improve the dissemination of scientific research, such as creating videos to accompany published papers and encouraging note-taking during seminars and presentations. The article suggests that the current system may be designed to create competition among scientists and proposes the idea of cooperation as a means to improve the system. [Extracted from the article]

Fluid shear stress (FSS) from blood flow, sensed by the vascular endothelial cells (ECs) that line all blood vessels, regulates vascular development during embryogenesis, controls adult vascular physiology and determines the location of atherosclerotic plaque formation. Although a number of papers have reported a crucial role for cell-cell adhesions or adhesion receptors in these processes, a recent publication has challenged this paradigm, presenting evidence that ECs can very rapidly align in fluid flow as single cells without cell–cell contacts. To address this controversy, four independent laboratories assessed EC alignment in fluid flow across a range of EC cell types. These studies demonstrate a strict requirement for cell-cell contact in shear stress sensing over timescales consistent with previous literature and inconsistent with the newly published data. [ABSTRACT FROM AUTHOR]

This document is an interview with Thomas Blake, the first author of a paper titled "Filopodial protrusion driven by density-dependent Ena-TOCA-1 interactions" published in the Journal of Cell Science. The paper explores the molecular mechanisms that drive cell motility in frog neurons during the development of the nervous system. The study shows that the protein TOCA-1 is directly involved in the extension of filopodia, which are dynamic finger-like structures made of actin filaments. The research also reveals that TOCA-1 works together with another protein called Ena to promote filopodia extension. The challenges of working with primary cells and the use of two-color imaging are discussed, as well as the author's role models in science and future research plans. [Extracted from the article]

The article features an interview with Cecilia Alejandra Vazquez, the first author of a paper on Junín virus published in the Journal of Cell Science. Vazquez discusses how the virus interacts with host cells, specifically targeting and degrading lipid droplets to fuel its life cycle. She also shares the challenges faced during the research and the importance of perseverance in scientific endeavors. Vazquez's work sheds light on the role of lipid droplets in viral replication and highlights the significance of understanding host-pathogen interactions for developing new therapies. [Extracted from the article]

This article is an interview with Valérie Cabana, the first author of a paper published in the Journal of Cell Science. The paper discusses the role of the AP-1 protein complex in the targeting of the ubiquitin ligase RNF13 to endosomes. The study reveals a novel non-canonical binding motif, involving a glutamine motif, that allows RNF13 to be directed to endosomes when the primary sorting motif is altered. The research provides new insights into protein trafficking and its regulatory mechanisms. Valérie Cabana faced challenges in detecting RNF13 and determining its precise cellular functions, but overcame them through various experimental approaches. The article also highlights significant findings, such as the retention of the dileucine-altered variant of RNF13 in the trans-Golgi network when combined with AP-1 knockdown. Valérie Cabana chose the Journal of Cell Science for publication due to its reputation and the prevalence of microscopy in their research. The article concludes with Valérie Cabana expressing gratitude for her mentors and discussing her motivation to pursue a career in science. [Extracted from the article]

Renata Basto, a scientist at the Institut Curie in Paris, France, is an Editor for the Journal of Cell Science. In an interview, she discusses her career path, her inspiration to become a scientist, and her current research on centrosome defects in cancer and mitotic spindle organization. Her lab aims to understand the roles of centrosomes and mechanisms of mitotic spindle assembly in development, health, and disease. The text also discusses various research projects related to neural stem cell death, mitotic spindle during neurogenesis, polyploidy, and cell size in relation to the cell cycle. The author emphasizes the importance of cell biology approaches and the need for more papers on specific topics such as cell cycle, mitosis, centrosomes, and microtubules. They also express their support for transparent peer review and offer advice to young scientists on career development and networking. Additionally, the author shares their passion for cooking and trying new recipes. [Extracted from the article]