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This article asserts that glycogen synthase kinase-3 is an endogenous inhibitor of snail transcription. The distinct architecture of epithelia is derived from the interactions of epithelial cells with each other, with the underlying basement membrane, and, less directly, with mesenchymal cells in the stroma. The central importance of E-cadherin for epithelial architecture leads to the novel hypothesis that epithelial cells may support signaling pathways that preserve E-cadherin expression as a means of preventing an EMT.

Shows that vitamin D[sub 3] induces E-cadherin and modulates beta-catenin-TCF-4 target genes in a manner opposite to that of beta-catenin, promoting the differentiation of colon carcinoma cells. Physical interaction of the vitamin D receptors with beta-catenin; Inhibitory action of actinomycin; Mechanism of actions of beta-catenin and plakoglobin.