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Your search keyword '"Krueger, Eugene W."' showing total 6 results
Start Over Author "Krueger, Eugene W." Journal journal of cell biology
6 results on '"Krueger, Eugene W."'

5. Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTC BP-1.

Author

Li Qiang, Hong Cao, Jing Chen, Weller, Shaun G., Krueger, Eugene W., Lizhi Zhang, Razidlo, Gina L., and McNiven, Mark A.

Subjects
*TUMORS, *STROMAL cells, *TISSUES, *METALLOPROTEINASES, *PANCREATIC tumors
Abstract

The process by which tumor cells mechanically invade through surrounding stroma into peripheral tissues is an essential component of metastatic dissemination. The directed recruitment of the metalloproteinase MT1-MMP to invadopodia plays a critical role in this invasive process. Here, we provide mechanistic insight into MT1-MMP cytoplasmic tail binding protein 1 (MTC BP-1) with respect to invadopodia formation, matrix remodeling, and invasion by pancreatic tumor cells. MTC BP-1 localizes to invadopodia and interacts with MT1-MMP. We find that this interaction displaces MT1-MMP from invadopodia, thereby attenuating their number and function and reducing the capacity of tumor cells to degrade matrix. Further, we observe an inverse correlation between MTC BP-1 and MT1-MMP expression both in cultured cell lines and human pancreatic tumors. Consistently, MTC BP-1-expressing cells show decreased ability to invade in vitro and metastasize in vivo. These findings implicate MTC BP-1 as an inhibitor of the metastatic process. [ABSTRACT FROM AUTHOR]

Published
2019
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6. Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1.

Author

Qiang L, Cao H, Chen J, Weller SG, Krueger EW, Zhang L, Razidlo GL, and McNiven MA

Subjects
Animals, Cell Line, Tumor, Cell Movement, Cell Proliferation, Dioxygenases antagonists & inhibitors, Dioxygenases metabolism, Humans, Intestinal Neoplasms metabolism, Intestinal Neoplasms mortality, Intestinal Neoplasms secondary, Intestine, Small metabolism, Intestine, Small pathology, Lymphatic Metastasis, Matrix Metalloproteinase 14 metabolism, Mice, Mice, Nude, Neoplasm Invasiveness, Pancreas metabolism, Pancreas pathology, Pancreatic Neoplasms metabolism, Pancreatic Neoplasms mortality, Pancreatic Neoplasms pathology, Podosomes metabolism, Podosomes pathology, Protein Binding, RNA, Small Interfering genetics, RNA, Small Interfering metabolism, Signal Transduction, Survival Analysis, Xenograft Model Antitumor Assays, Dioxygenases genetics, Gene Expression Regulation, Neoplastic, Intestinal Neoplasms genetics, Matrix Metalloproteinase 14 genetics, Pancreatic Neoplasms genetics, Podosomes genetics
Abstract

The process by which tumor cells mechanically invade through surrounding stroma into peripheral tissues is an essential component of metastatic dissemination. The directed recruitment of the metalloproteinase MT1-MMP to invadopodia plays a critical role in this invasive process. Here, we provide mechanistic insight into MT1-MMP cytoplasmic tail binding protein 1 (MTCBP-1) with respect to invadopodia formation, matrix remodeling, and invasion by pancreatic tumor cells. MTCBP-1 localizes to invadopodia and interacts with MT1-MMP. We find that this interaction displaces MT1-MMP from invadopodia, thereby attenuating their number and function and reducing the capacity of tumor cells to degrade matrix. Further, we observe an inverse correlation between MTCBP-1 and MT1-MMP expression both in cultured cell lines and human pancreatic tumors. Consistently, MTCBP-1-expressing cells show decreased ability to invade in vitro and metastasize in vivo. These findings implicate MTCBP-1 as an inhibitor of the metastatic process., (© 2018 Qiang et al.)

Published
2019
Full Text
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