Author: "Ioannou, Maria" / Journal: journal of cell biology - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Ioannou, Maria"' showing total 7 results

Start Over Author "Ioannou, Maria" Journal journal of cell biology

Author: Ralhan, Isha, primary, Chang, Jinlan, additional, Moulton, Matthew J., additional, Goodman, Lindsey D., additional, Lee, Nathanael Y.J., additional, Plummer, Greg, additional, Pasolli, H. Amalia, additional, Matthies, Doreen, additional, Bellen, Hugo J., additional, and Ioannou, Maria S., additional
Published: 2023
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Author: Ralhan, Isha, primary, Chang, Chi-Lun, additional, Lippincott-Schwartz, Jennifer, additional, and Ioannou, Maria S., additional
Published: 2021
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Author: Chang, Chi-Lun, primary, Weigel, Aubrey V., additional, Ioannou, Maria S., additional, Pasolli, H. Amalia, additional, Xu, C. Shan, additional, Peale, David R., additional, Shtengel, Gleb, additional, Freeman, Melanie, additional, Hess, Harald F., additional, Blackstone, Craig, additional, and Lippincott-Schwartz, Jennifer, additional
Published: 2019
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Author: Condon, Nicholas D., primary, Heddleston, John M., additional, Chew, Teng-Leong, additional, Luo, Lin, additional, McPherson, Peter S., additional, Ioannou, Maria S., additional, Hodgson, Louis, additional, Stow, Jennifer L., additional, and Wall, Adam A., additional
Published: 2018
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Author: Ioannou, Maria S., primary, Bell, Emily S., additional, Girard, Martine, additional, Chaineau, Mathilde, additional, Hamlin, Jason N.R., additional, Daubaras, Mark, additional, Monast, Anie, additional, Park, Morag, additional, Hodgson, Louis, additional, and McPherson, Peter S., additional
Published: 2015
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Author: Chi-Lun Chang, Weigel, Aubrey V., Ioannou, Maria S., Pasolli, H. Amalia, Xu, C. Shan, Peale, David R., Shtengel, Gleb, Freeman, Melanie, Hess, Harald F., Blackstone, Craig, and Lippincott-Schwartz, Jennifer
Subjects: *FAMILIAL spastic paraplegia, *FATTY acids, *LIPIDS, *PEROXISOMES, *PERILIPIN, *ADIPOGENESIS, *ORGANELLES
Abstract: Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various organelles including peroxisomes. Here, we show that the hereditary spastic paraplegia protein M1 Spastin, a membrane-bound AAA ATPase found on LDs, coordinates fatty acid (FA) trafficking from LDs to peroxisomes through two interrelated mechanisms. First, M1 Spastin forms a tethering complex with peroxisomal ABCD1 to promote LD-peroxisome contact formation. Second, M1 Spastin recruits the membraneshaping ESCRT-III proteins IST1 and CHMP1B to LDs via its MIT domain to facilitate LD-to-peroxisome FA trafficking, possibly through IST1- and CHMP1B-dependent modifications in LD membrane morphology. Furthermore, LD-to-peroxisome FA trafficking mediated by M1 Spastin is required to relieve LDs of lipid peroxidation. M1 Spastin's dual roles in tethering LDs to peroxisomes and in recruiting ESCRT-III components to LD-peroxisome contact sites for FA trafficking may underlie the pathogenesis of diseases associated with defective FA metabolism in LDs and peroxisomes. [ABSTRACT FROM AUTHOR]
Published: 2019
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